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Guidelines

MIRAGE

very low density lipoprotein receptor

Summary

Gene Symbol

VLDLR

Organism

Homo sapiens (human)

External Links

NCBI Gene

7436

PubChem

7436

Alliance of Genome Resources

HGNC:12698

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cholesterol metabolism
Coated pit
Disulfide bond
EGF-like domain
Endocytosis
Glycoprotein
Host-virus interaction
Intellectual disability
Isopeptide bond
Lipid transport
Lipoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation
VLDL

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A7P0T897
A0A7P0T9P7
Q5VVF5
P98155

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
lipid transport	IEA
receptor-mediated endocytosis	IDA	10571240
signal transduction	TAS	10380922
nervous system development	TAS	10380922
memory	TAS	7550352

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

plasma lipoprotein particle clearance [inference]

very-low-density lipoprotein particle clearance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

anatomical structure development [inference]

ventral spinal cord development

system development [inference]

nervous system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

organic substance transport [inference]

lipid transport

protein transport [inference]

glycoprotein transport

carbohydrate derivative transport [inference]

glycoprotein transport

nitrogen compound transport [inference]

protein transport [inference]

glycoprotein transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

glycoprotein transport

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of dendrite development

regulation of developmental process [inference]

regulation of dendrite development [inference]

positive regulation of dendrite development

positive regulation of developmental process [inference]

positive regulation of dendrite development

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

reelin-mediated signaling pathway

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of dendrite development [inference]

positive regulation of dendrite development

regulation of synapse organization [inference]

regulation of synapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development [inference]

positive regulation of dendrite development

regulation of cell junction assembly [inference]

regulation of synapse assembly

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
lysosomal membrane	TAS
plasma membrane	TAS
plasma membrane	IBA
clathrin-coated pit	IEA
membrane	IDA	15082773

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

triglyceride-rich plasma lipoprotein particle [inference]

very-low-density lipoprotein particle

receptor complex

cellular anatomical entity [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

clathrin-coated pit

cell junction [inference]

synapse [inference]

glutamatergic synapse

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
low-density lipoprotein particle receptor activity	TAS	10380922
calcium ion binding	IEA
protein binding	IPI	10571240 10571241 17330141 17548821 20223215 32296183 33961781 8083232
very-low-density lipoprotein particle receptor activity	TAS	20005821
very-low-density lipoprotein particle receptor activity	IDA	8083232

GO Hierarchy

molecular function

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

protein-lipid complex binding [inference]

lipoprotein particle binding [inference]

very-low-density lipoprotein particle binding

cargo receptor activity

lipoprotein particle receptor activity [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

reelin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dehydrogenase

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 4** entries
Gene Ontology
NAD+ binding
fatty acid metabolic process
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
oxidoreductase activity

Displaying **all 5** entries
InterPro
3-hydroxyacyl-CoA dehydrogenase, C-terminal
3-hydroxyacyl-CoA dehydrogenase, NAD binding
6-phosphogluconate dehydrogenase, domain 2
6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
NAD(P)-binding domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070556	cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:1307	dementia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3949	FB:FBgn0051092
Xenopus tropicalis	7436	Xenbase:XB-GENE-971958
Drosophila melanogaster	7804	FB:FBgn0051092
Drosophila melanogaster	16835	FB:FBgn0066101
Mus musculus	22359	Xenbase:XB-GENE-971958	MOUSE25115
Rattus norvegicus	25696		RATNO20476
Xenopus tropicalis	174116	Xenbase:XB-GENE-971958
Bos taurus	282123		BOVIN34388
Drosophila melanogaster	300438	FB:FBgn0051092
Danio rerio	393897		DANRE00230

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025