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von Willebrand factor
Summary
- Gene Symbol
-
- VWF
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell adhesion
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Extracellular matrix
- Glycoprotein
- Proteomics identification
- Reference proteome
- Repeat
- Signal
- von Willebrand disease
- Proteins
| UniProt | Protein Name |
|---|---|
| P04275 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell adhesion | ||
| blood coagulation | ||
| blood coagulation | ||
| hemostasis | ||
| response to wounding |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| extracellular region | ||
| extracellular space |
| GO Term | Evidence Code | PMID |
|---|---|---|
| protease binding | ||
| protease binding | ||
| integrin binding | ||
| extracellular matrix structural constituent | ||
| protein binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- von willebrand factor
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| blood coagulation |
| cell-substrate adhesion |
| InterPro |
|---|
| Serine protease inhibitor-like superfamily |
| Trypsin Inhibitor-like, cysteine rich domain |
| VWF/SSPO/Zonadhesin-like, cysteine-rich domain |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060224 | atrial fibrillation | |
| DOID:0060573 | von Willebrand's disease 1 | |
| DOID:0060574 | von Willebrand's disease 2 | |
| DOID:0111054 | von Willebrand's disease 3 | |
| DOID:12531 | von Willebrand's disease | |
| DOID:13241 | Behcet's disease | |
| DOID:2217 | Bernard-Soulier syndrome | |
| DOID:2224 | essential thrombocythemia | |
| DOID:6432 | pulmonary hypertension | |
| DOID:783 | end stage renal disease |
