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mixed lineage kinase domain-like

Summary

Gene Symbol

Mlkl

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

74568

PubChem

74568

Alliance of Genome Resources

MGI:1921818

Annotation

Keyword

3D-structure
ATP-binding
Alternative splicing
Cell membrane
Coiled coil
Cytoplasm
Necrosis
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9D2Y4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
defense response to virus	IDA	32200799 32296175
defense response to virus	IMP	27321907
protein homotrimerization	ISS
protein homotrimerization	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell death [inference]

programmed cell death [inference]

programmed necrotic cell death [inference]

necroptotic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

execution phase of necroptosis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

defense response to symbiont [inference]

defense response to virus

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	32200799 32296175
cytoplasm	ISS
cytoplasm	ISO
cytoplasm	IDA	32200799 32296175
cytoplasm	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
protein kinase activity	IDA	24012422
protein serine/threonine kinase activity	IBA
protein binding	IPI	22265413 26559832 27321907 38173512
ATP binding	ISO
ATP binding	IDA	24012422

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

protein serine/threonine kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

protein serine/threonine kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

protein serine/threonine kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mixed lineage kinase domain-like

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ATP binding
cell surface receptor signaling pathway
nucleotide binding

Displaying **all 4** entries
InterPro
Adaptor protein Cbl, N-terminal domain superfamily
Protein kinase domain
Protein kinase-like domain superfamily
Serine-threonine/tyrosine-protein kinase, catalytic domain

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements