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inositol polyphosphate-5-phosphatase E

Summary

Gene Symbol

INPP5E

Organism

Pan troglodytes (chimpanzee)

External Links

NCBI Gene: 748603
KEGG Gene ID: ptr:748603
PubChem: 748603

Annotation

Keyword

Cell membrane
Cilium
Cytoskeleton
Golgi apparatus
Hydrolase
Lipid metabolism
Methylation
Nucleus
Phosphoprotein
Prenylation
Reference proteome
Repeat

Proteins

Displaying **all 2** entries
UniProt	Protein Name
K7B557
A0FI79	72 kDa inositol polyphosphate 5-phosphatase Inositol polyphosphate-5-phosphatase E Phosphatidylinositol 4,5-bisphosphate 5-phosphatase Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
phosphatidylinositol dephosphorylation	IEA	22301074 30032202

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Golgi apparatus	IEA	30032202
nucleus	IEA	30032202
axoneme	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

axoneme

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA	30032202
inositol-polyphosphate 5-phosphatase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity [inference]

inositol trisphosphate phosphatase activity [inference]

inositol-polyphosphate 5-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Hominidae

Group Name

phosphatidylinositol polyphosphate 5-phosphatase type IV

Functional Category

F: Nucleotide transport and metabolism
I: Lipid transport and metabolism
V: Defense mechanisms

Displaying **all 7** entries
Gene Ontology
hydrolase activity
inositol-polyphosphate 5-phosphatase activity
lipid metabolic process
organophosphate metabolic process
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
phosphatidylinositol-3-phosphate biosynthetic process

Displaying **all 3** entries
InterPro
72kDa inositol polyphosphate 5-phosphatase
Endonuclease/exonuclease/phosphatase superfamily
Inositol polyphosphate-related phosphatase

KEGG BRITE Database

Orthology

K20278

Name

inositol polyphosphate 5-phosphatase INPP5E [EC:3.1.3.36]

References

10764818

Rhea

RHEA:22764

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

Enzyme

3.1.3.36

PMID

RHEA:25528

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)

Enzyme

3.1.3.86

PMID

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Homo sapiens	56623	9606_0:0045fe	HUMAN99304
Mus musculus	64436		MOUSE35589
Rattus norvegicus	114089		RATNO27251
Bos taurus	506349		BOVIN03417
Danio rerio	606579		DANRE36968
Canis lupus familiaris	607443		CANLF19266
Macaca mulatta	710121		MACMU12924
Equus caballus	100068731		HORSE23894
Ornithorhynchus anatinus	100092732		ORNAN21028
Taeniopygia guttata	100218296		TAEGU06803

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Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements