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X-ray repair cross complementing 1

Summary

Gene Symbol

XRCC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7515

PubChem

7515

Alliance of Genome Resources

HGNC:12828

Annotation

Keyword

3D-structure
Chromosome
DNA repair
Isopeptide bond
Neurodegeneration
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q59HH7
B2RCY5
P18887	X-ray repair cross-complementing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
single strand break repair	IMP	28002403
response to hypoxia	IEA
base-excision repair	IDA	19589734 34102106 34811483
base-excision repair	IBA
double-strand break repair	IDA	19589734

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

musculoskeletal movement [inference]

voluntary musculoskeletal movement

multicellular organismal movement [inference]

musculoskeletal movement [inference]

voluntary musculoskeletal movement

developmental process [inference]

anatomical structure morphogenesis [inference]

cerebellum morphogenesis

anatomical structure development [inference]

hippocampus development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to oxidative stress [inference]

response to hydroperoxide

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to xenobiotic stimulus

response to oxygen-containing compound [inference]

response to hydroperoxide

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

single strand break repair

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

base-excision repair

double-strand break repair

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligation [inference]

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligase activity [inference]

positive regulation of DNA ligase activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligation [inference]

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligase activity [inference]

positive regulation of DNA ligase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligation [inference]

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligase activity [inference]

positive regulation of DNA ligase activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligation [inference]

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligase activity [inference]

positive regulation of DNA ligase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of response to stimulus [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

negative regulation of response to stimulus [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA metabolic process [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligation [inference]

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

regulation of DNA ligase activity [inference]

positive regulation of DNA ligase activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

positive regulation of DNA ligation [inference]

positive regulation of DNA ligase activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of single strand break repair

regulation of single strand break repair [inference]

positive regulation of single strand break repair

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of protein ADP-ribosylation

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of ligase activity [inference]

positive regulation of DNA ligase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of ligase activity [inference]

positive regulation of DNA ligase activity

negative regulation of catalytic activity [inference]

negative regulation of transferase activity [inference]

negative regulation of protein ADP-ribosylation

regulation of transferase activity [inference]

regulation of protein ADP-ribosylation [inference]

negative regulation of protein ADP-ribosylation

negative regulation of transferase activity [inference]

negative regulation of protein ADP-ribosylation

regulation of ligase activity [inference]

positive regulation of ligase activity [inference]

positive regulation of DNA ligase activity

regulation of DNA ligase activity [inference]

positive regulation of DNA ligase activity

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IEA
chromatin	IDA	28002403
nucleus	IBA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

nucleotide-excision repair complex [inference]

ERCC4-ERCC1 complex

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

site of DNA damage

chromosomal region [inference]

chromosome, telomeric region

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GO Term	Evidence Code	PMID
protein binding	IPI	14755728 15044383 15380105 15520167 15555565 16713569 17353262 17396150 18923427 18971944 19155274 19336415 19851285 19934257 20351257 21637298 23178593 24778456 24981860 25456813 25609649 26496610 28514442 33961781 34102106 35271311
enzyme binding	IPI	19589734 8532526
oxidized DNA binding	IMP	28002403
poly-ADP-D-ribose binding	IDA	14500814 34811483
ADP-D-ribose modification-dependent protein binding	IDA	34102106

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endodeoxyribonuclease activity [inference]

3' overhang single-stranded DNA endodeoxyribonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endodeoxyribonuclease activity [inference]

3' overhang single-stranded DNA endodeoxyribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endodeoxyribonuclease activity [inference]

3' overhang single-stranded DNA endodeoxyribonuclease activity

binding [inference]

protein binding

enzyme binding

modification-dependent protein binding [inference]

ADP-D-ribose modification-dependent protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding [inference]

oxidized DNA binding

carbohydrate derivative binding [inference]

poly-ADP-D-ribose binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA repair protein

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
base-excision repair
damaged DNA binding
single strand break repair

Displaying **all 2** entries
InterPro
DNA-repair protein Xrcc1, N-terminal
Galactose-binding-like domain superfamily

Disease

Disease Ontology

Displaying entries **11 - 20** of 47 in total

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DO ID	Disease Name	Source
DOID:127	leiomyoma	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1790	malignant mesothelioma	Alliance of Genome Resources
DOID:1793	pancreatic cancer	Alliance of Genome Resources
DOID:1875	impotence	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2600	laryngeal carcinoma	Alliance of Genome Resources
DOID:2671	transitional cell carcinoma	Alliance of Genome Resources
DOID:2773	contact dermatitis	Alliance of Genome Resources
DOID:3008	invasive ductal carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7515	Xenbase:XB-GENE-968809
Mus musculus	22594		MOUSE54590
Rattus norvegicus	84495		RATNO19694
Danio rerio	445480		DANRE10737
Pan troglodytes	456094		PANTR18513
Canis lupus familiaris	476447		CANLF00985
Bos taurus	616905		BOVIN11228
Macaca mulatta	711457		MACMU18958
Equus caballus	100070201		HORSE02100
Ciona intestinalis	100183893		CIOIN12344

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements