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MIRAGE
zeta chain of T cell receptor associated protein kinase 70
Summary
- Gene Symbol
-
- ZAP70
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Acetylation
- Adaptive immunity
- Alternative splicing
- Cell membrane
- Cytoplasm
- Disease variant
- Isopeptide bond
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Repeat
- SCID
- SH2 domain
- Tyrosine-protein kinase
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P43403 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| adaptive immune response | ||
| protein phosphorylation | ||
| protein phosphorylation | ||
| immune response | ||
| transmembrane receptor protein tyrosine kinase signaling pathway |
|
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| phosphotyrosine residue binding | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity | ||
| protein tyrosine kinase activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- protein kinase
- Functional Category
-
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| kinase activity |
| non-membrane spanning protein tyrosine kinase activity |
| nucleotide binding |
| phosphorylation |
| transferase activity |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0111943 | immunodeficiency 48 | |
| DOID:627 | severe combined immunodeficiency |
