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solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Summary

Gene Symbol

Slc24a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

76376

PubChem

76376

Alliance of Genome Resources

MGI:1923626

Annotation

Keyword

Alternative splicing
Antiport
Calcium transport
Cell membrane
Glycoprotein
Phosphoprotein
Potassium transport
Reference proteome
Repeat
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BUN9	Na(+)/K(+)/Ca(2+)-exchange protein 2 Retinal cone Na-Ca+K exchanger Solute carrier family 24 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
calcium ion transport	IDA	16407245
intracellular calcium ion homeostasis	ISO
intracellular calcium ion homeostasis	IMP	16407245
intracellular calcium ion homeostasis	IBA
learning	IMP	16407245

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

behavior [inference]

learning or memory [inference]

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

neuron cellular homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

potassium ion transmembrane transport

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

organic substance transport [inference]

calcium ion transport

calcium ion import

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol [inference]

calcium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

calcium ion import across plasma membrane

establishment of localization in cell

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission [inference]

long-term synaptic potentiation

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
membrane	IDA	16407245
presynapse	IDA	26410028

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
calcium channel activity	IDA	16407245
calcium channel activity	IBA
calcium, potassium:sodium antiporter activity	ISO	18166528
calcium, potassium:sodium antiporter activity	IBA
symporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

solute:potassium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium channel activity

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity [inference]

calcium, potassium:sodium antiporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium/potassium/calcium exchanger

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
calcium channel activity
calcium ion transport
calcium, potassium
intracellular calcium ion homeostasis

Displaying **all 3** entries
InterPro
NCX, central ion-binding domain superfamily
Sodium/calcium exchanger membrane region
Sodium/potassium/calcium exchanger

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	9187	FB:FBgn0028704
Homo sapiens	25769	Xenbase:XB-GENE-483618	HUMAN96554
Xenopus tropicalis	45248	Xenbase:XB-GENE-483618
Drosophila melanogaster	56814	FB:FBgn0028704
Xenopus tropicalis	76376	Xenbase:XB-GENE-483618
Rattus norvegicus	84550	Xenbase:XB-GENE-483618	RATNO34268
Xenopus tropicalis	172834	Xenbase:XB-GENE-483618
Drosophila melanogaster	214111	FB:FBgn0028704
Pan troglodytes	473181		PANTR43715
Canis lupus familiaris	481554		CANLF02202

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements