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zona pellucida glycoprotein 2

Summary

Gene Symbol

ZP2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7783

PubChem

7783

Alliance of Genome Resources

HGNC:13188

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Fertilization
Glycoprotein
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q05996	Zona pellucida glycoprotein 2 Zona pellucida protein A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
binding of sperm to zona pellucida	ISS	22472438
binding of sperm to zona pellucida	IBA
regulation of acrosome reaction	IDA	11751269 20394732
prevention of polyspermy	ISS	22472438
prevention of polyspermy	IBA

GO Hierarchy

biological process

cellular process [inference]

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

reproductive process [inference]

sperm-egg recognition [inference]

binding of sperm to zona pellucida

prevention of polyspermy

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

regulation of reproductive process [inference]

regulation of acrosome reaction

regulation of fertilization [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

negative regulation of reproductive process [inference]

negative regulation of fertilization [inference]

prevention of polyspermy

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GO Term	Evidence Code	PMID
extracellular region	TAS
multivesicular body	ISS
endoplasmic reticulum	ISS
plasma membrane	ISS
egg coat	IDA	29895852

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

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GO Term	Evidence Code	PMID
protein binding	IPI	15950651 23355646 28886344
coreceptor activity	TAS	8385033
acrosin binding	IBA
acrosin binding	IPI	15950651
structural constituent of egg coat	ISS

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent [inference]

structural constituent of egg coat

binding [inference]

protein binding

enzyme binding [inference]

acrosin binding

identical protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

coreceptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

latent-transforming growth factor beta-binding

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	7783	Xenbase:XB-GENE-976172
Mus musculus	22787	Xenbase:XB-GENE-976172	MOUSE56139
Rattus norvegicus	81828	Xenbase:XB-GENE-976172	RATNO21160
Sus scrofa	396846		PIGXX20795
Xenopus tropicalis	398089	Xenbase:XB-GENE-976172
Canis lupus familiaris	403988		CANLF16504
Pan troglodytes	453979		PANTR11912
Felis catus	493977		FELCA34971
Macaca mulatta	697458		MACMU27418
Oryctolagus cuniculus	100009069		RABIT11202