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neurotrophin 5

Summary

Gene Symbol

Ntf5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

78405

PubChem

78405

Alliance of Genome Resources

MGI:97381

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Glycoprotein
Growth factor
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q80VU4	Neurotrophin-5 Neutrophic factor 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
signal transduction	IEA
transmembrane receptor protein tyrosine kinase signaling pathway	IBA
ganglion mother cell fate determination	IMP	10681461
long-term memory	IMP	10869436
sensory organ boundary specification	IMP	10479455

GO Hierarchy

biological process

cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

neurotrophin signaling pathway [inference]

nerve growth factor signaling pathway

cellular developmental process [inference]

cell fate determination [inference]

ganglion mother cell fate determination

cell differentiation [inference]

neuron differentiation [inference]

mechanoreceptor differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory [inference]

long-term memory

pattern specification process [inference]

regionalization [inference]

formation of animal organ boundary [inference]

sensory organ boundary specification

behavior [inference]

learning or memory [inference]

memory [inference]

long-term memory

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

innervation

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of anatomical boundary [inference]

formation of animal organ boundary [inference]

sensory organ boundary specification

anatomical structure development [inference]

tissue development [inference]

epidermis development

nerve development

animal organ development [inference]

sensory organ development [inference]

taste bud development

cellular developmental process [inference]

cell fate determination [inference]

ganglion mother cell fate determination

cell differentiation [inference]

neuron differentiation [inference]

mechanoreceptor differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

ameloblast differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

neurotrophin signaling pathway [inference]

nerve growth factor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IBA
endoplasmic reticulum lumen	TAS
synaptic vesicle	IBA
axon	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nerve growth factor receptor binding	IBA
neurotrophin p75 receptor binding	TAS	8873083
growth factor activity	IBA
growth factor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

neurotrophin receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

death receptor binding [inference]

nerve growth factor receptor binding

receptor ligand activity [inference]

growth factor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Neurotrophin-4

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying entries **1 - 10** of 13 in total

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Gene Ontology
growth factor activity
memory
modulation of chemical synaptic transmission
negative regulation of neuron apoptotic process
nerve development
nerve growth factor receptor binding
nerve growth factor signaling pathway
neuron projection morphogenesis
peripheral nervous system development
positive regulation of peptidyl-serine phosphorylation

Displaying **all 4** entries
InterPro
Cystine-knot cytokine
Nerve growth factor conserved site
Nerve growth factor-like
Nerve growth factor-related

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4909	Xenbase:XB-GENE-1013492	HUMAN44947
Rattus norvegicus	25730	Xenbase:XB-GENE-1013492	RATNO16470
Xenopus tropicalis	78405	Xenbase:XB-GENE-1013492
Bos taurus	506660		BOVIN11490
Canis lupus familiaris	611987		CANLF00824
Macaca mulatta	718534		MACMU18388
Pan troglodytes	747850		PANTR18886
Equus caballus	100054859		HORSE01060
Callithrix jacchus	100392049		CALJA24729
Sus scrofa	100511085		PIGXX28227