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Guidelines

MIRAGE

mannosyl-oligosaccharide glucosidase

Summary

Gene Symbol

MOGS

Aliases

CWH41
DER7
GCS1
glucosidase I
processing A-glucosidase I

Organism

Homo sapiens (human)

External Links

NCBI Gene

7841

HGNC

24862

KEGG Gene ID

hsa:7841

PubChem

7841

Alliance of Genome Resources

HGNC:24862

JoGo

MOGS

TogoVar

MOGS

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosidase
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A384MDR6	Glucosidase I
Q58F09	Glucosidase I
Q13724	Processing A-glucosidase I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein folding	TAS
protein N-linked glycosylation	IBA
oligosaccharide metabolic process	IEA
viral protein processing	TAS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein N-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein N-linked glycosylation

cellular process [inference]

protein folding

viral process [inference]

viral protein processing

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IBA
membrane	HDA	19946888
extracellular exosome	HDA	19056867 19199708

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	TAS
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IBA
glucosidase activity	TAS	7635146

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

glucosidase activity

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

mannosyl-oligosaccharide glucosidase

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 4** entries
Gene Ontology
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
protein N-linked glycosylation

Displaying **all 6** entries
InterPro
Glycoside hydrolase family 63
Glycosyl hydrolase family 63, C-terminal
Glycosyl hydrolase family 63, N-terminal domain superfamily
Glycosyl hydrolase family 63, N-terminal
Six-hairpin glycosidase superfamily
Six-hairpin glycosidase-like superfamily

Human Protein Atlas

ENSG00000115275

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01228

Name

mannosyl-oligosaccharide glucosidase [EC:3.2.1.106]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05979	3.2.1.106	G57930PW	G18948TG

Rhea

H₂O

β-D-glucose

Enzyme

3.2.1.106

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070254	congenital disorder of glycosylation type IIb	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **31 - 40** of 54 in total

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HPO ID	HPO Term
HP:0002098	Respiratory distress
HP:0002104	Apnea
HP:0002240	Hepatomegaly
HP:0002286	Fair hair
HP:0002720	Decreased circulating IgA level
HP:0002757	Recurrent fractures
HP:0002791	Hypoventilation
HP:0002850	Decreased circulating total IgM
HP:0002943	Thoracic scoliosis
HP:0003241	External genital hypoplasia

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:606056	MOGS-congenital disorder of glycosylation
ORPHA:79330	MOGS-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

MOGS-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIb; CDG2B

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025