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Guidelines
MIRAGE
paired box 8
Summary
- Gene Symbol
-
- PAX8
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Congenital hypothyroidism
- DNA-binding
- Developmental protein
- Differentiation
- Disease variant
- Nucleus
- Paired box
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Transcription regulation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of transcription by RNA polymerase II | ||
| pronephros development | ||
| cellular response to gonadotropin stimulus | ||
| otic vesicle development | ||
| positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
negative regulation of cellular process [inference]
negative regulation of programmed cell death [inference]
negative regulation of apoptotic process [inference]
negative regulation of developmental process [inference]
regulation of developmental process [inference]
regulation of cell differentiation [inference]
negative regulation of developmental process [inference]
regulation of apoptotic process involved in development [inference]
regulation of apoptotic process involved in morphogenesis [inference]
negative regulation of apoptotic process involved in development [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
regulation of programmed cell death [inference]
regulation of apoptotic process
negative regulation of apoptotic process [inference]
regulation of apoptotic process involved in development [inference]
regulation of apoptotic process involved in morphogenesis [inference]
negative regulation of apoptotic process involved in development [inference]
regulation of mesenchymal cell apoptotic process [inference]
negative regulation of programmed cell death [inference]
negative regulation of apoptotic process [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
negative regulation of programmed cell death [inference]
negative regulation of apoptotic process [inference]
regulation of multicellular organismal process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| DNA-binding transcription activator activity, RNA polymerase II-specific | ||
| DNA binding | ||
| DNA binding | ||
| DNA-binding transcription factor activity | ||
| thyroid-stimulating hormone receptor activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- paired box
- Functional Category
-
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
- X: Mobilome: prophages, transposons
| InterPro |
|---|
| Homeobox-like domain superfamily |
| PAX family |
| Paired DNA-binding domain |
| Paired domain |
| Winged helix-like DNA-binding domain superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050328 | congenital hypothyroidism | |
| DOID:0070124 | congenital nongoitrous hypothyroidism 2 |
