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cysteine rich with EGF like domains 1

Summary

Gene Symbol

CRELD1

Organism

Homo sapiens (human)

External Links

NCBI Gene

78987

PubChem

78987

Alliance of Genome Resources

HGNC:14630

JoGo

CRELD1

TogoVar

CRELD1

Annotation

Keyword

Alternative splicing
Calcium
Disease variant
Disulfide bond
EGF-like domain
Epilepsy
Glycoprotein
Intellectual disability
Isomerase
Membrane
Proteomics identification
Redox-active center
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A804HJJ0	Cysteine-rich with EGF-like domain protein 1
A0A804HKP7	Cysteine-rich with EGF-like domain protein 1
A0A669KAV0
Q96HD1	Cysteine-rich with EGF-like domain protein 1
A0A669KBB3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endocardial cushion development	TAS	18076106
cardiac septum development	TAS	18076106

GO Hierarchy

biological process

developmental process [inference]

anatomical structure development [inference]

cardiac septum development

tissue development [inference]

mesenchyme development [inference]

endocardial cushion development

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane	IEA
collagen-containing extracellular matrix	HDA	28675934
glutamatergic synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein disulfide isomerase activity	IEA
extracellular matrix structural constituent	RCA	28675934
calcium ion binding	IEA
protein binding	IPI	20508391 32814053

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

intramolecular oxidoreductase activity [inference]

intramolecular oxidoreductase activity, transposing S-S bonds [inference]

protein disulfide isomerase activity

catalytic activity, acting on a protein [inference]

protein disulfide isomerase activity

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cysteine-rich with egf-like domain

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 7** entries
InterPro
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
Furin-like repeat
Growth factor receptor cysteine-rich domain superfamily
Laminin-type EGF domain
NOTCH1 EGF-like calcium-binding domain