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MIRAGE
FTO alpha-ketoglutarate dependent dioxygenase

Summary
Gene Symbol
  • FTO
Organism
Homo sapiens (human)
NCBI Gene
79068
PubChem
79068
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • Dioxygenase
  • Disease variant
  • Iron
  • Metal-binding
  • Nucleus
  • Obesity
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transferase
Proteins
Displaying all 4 entries
UniProt Protein Name
B3KU60
  • Fat mass and obesity-associated protein
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
Q9C0B1
  • Fat mass and obesity-associated protein
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
Q99770
A0A1B0GTC5
  • Fat mass and obesity-associated protein
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 11 in total
GO Term Evidence Code PMID
temperature homeostasis
DNA dealkylation involved in DNA repair
regulation of lipid storage
snRNA processing
regulation of multicellular organism growth
GO Hierarchy
Displaying entries 1 - 5 of 11 in total
GO Term Evidence Code PMID
protein binding
ferrous iron binding
ferrous iron binding
transferase activity
oxidative RNA demethylase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
alpha-ketoglutarate-dependent dioxygenase FTO
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying entries 1 - 10 of 11 in total
Gene Ontology
DNA dealkylation involved in DNA repair
RNA repair
dioxygenase activity
ferrous iron binding
mRNA N6-methyladenosine dioxygenase activity
metal ion binding
oxidative RNA demethylase activity
oxidative single-stranded DNA demethylation
oxidative single-stranded RNA demethylation
oxidoreductase activity
Displaying all 5 entries
InterPro
Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
Alpha-ketoglutarate-dependent dioxygenase FTO
FTO, C-terminal domain superfamily
Disease
Disease Ontology
Displaying entries 1 - 10 of 13 in total
DO ID Disease Name Source
DOID:0080334 aortic valve disease 2
DOID:10763 hypertension
DOID:10825 essential hypertension
DOID:1287 cardiovascular system disease
DOID:13963 nuclear senile cataract
DOID:3393 coronary artery disease
DOID:4450 renal cell carcinoma
DOID:4467 clear cell renal cell carcinoma
DOID:5844 myocardial infarction
DOID:9352 type 2 diabetes mellitus
Ortholog
Displaying entries 21 - 30 of 77 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
101009424 PAPAN16623
101039741 SAIBB28225
101072340 TAKRU07852
101098594 FELCA33938
101145301 GORGO11661
101330551 TURTR15698
101572039 OCTDE15002
101604966 JACJA16511
101672201 MUSPF16849
101700280 HETGA10176
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025