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Guidelines

MIRAGE

dual oxidase 2

Summary

Gene Symbol

Duox2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

79107

PubChem

79107

Alliance of Genome Resources

RGD:628761

Annotation

Keyword

Alternative splicing
Calcium
Cell junction
Cell membrane
Disulfide bond
FAD
Glycoprotein
Hydrogen peroxide
Metal-binding
NADP
Reference proteome
Repeat
Signal
Thyroid hormones biosynthesis
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ES45	Large NOX 2 Long NOX 2 NADH/NADPH thyroid oxidase THOX2 Thyroid oxidase 2

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
thyroid hormone generation	TAS	12538618
thyroid hormone generation	IEA
defense response	IBA
response to oxidative stress	IEA
fertilization	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

catabolic process [inference]

cellular catabolic process [inference]

hydrogen peroxide catabolic process

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

biosynthetic process [inference]

hormone biosynthetic process

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

hormone metabolic process

thyroid hormone metabolic process

thyroid hormone generation

hormone biosynthetic process

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic substance metabolic process [inference]

hydrogen peroxide metabolic process [inference]

organic cyclic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

organic substance catabolic process [inference]

hydrogen peroxide catabolic process

organic substance biosynthetic process [inference]

hydrogen peroxide biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

cellular metabolic process [inference]

cellular modified amino acid metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

cellular aromatic compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

thyroid hormone metabolic process

thyroid hormone generation

cellular catabolic process [inference]

hydrogen peroxide catabolic process

cellular biosynthetic process [inference]

hydrogen peroxide biosynthetic process

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

hydrogen peroxide metabolic process [inference]

reactive oxygen species biosynthetic process [inference]

hydrogen peroxide biosynthetic process

cellular detoxification [inference]

cellular oxidant detoxification

reproductive process [inference]

fertilization

multicellular organismal process [inference]

multicellular organism growth

developmental process [inference]

anatomical structure morphogenesis [inference]

adenohypophysis morphogenesis

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

cuticle development

animal organ development [inference]

gland development [inference]

thyroid gland development

inner ear development

growth [inference]

developmental growth [inference]

multicellular organism growth

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to organophosphorus [inference]

response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP

response to oxygen-containing compound [inference]

response to cAMP

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility

positive regulation of cellular process [inference]

positive regulation of cell motility

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

positive regulation of wound healing

positive regulation of response to wounding [inference]

positive regulation of wound healing

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility

regulation of cell motility [inference]

positive regulation of cell motility

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process

thyroid hormone metabolic process

thyroid hormone generation

hormone biosynthetic process

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISS
endoplasmic reticulum	ISO
cytosol	ISS
cytosol	ISO
plasma membrane	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

cell junction [inference]

anchoring junction

cell leading edge

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

apical part of cell

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GO Term	Evidence Code	PMID
peroxidase activity	IEA
calcium ion binding	ISO
calcium ion binding	IEA
NAD(P)H oxidase H2O2-forming activity	ISO
NAD(P)H oxidase H2O2-forming activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

superoxide-generating NAD(P)H oxidase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

antioxidant activity [inference]

peroxidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Dual oxidase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
calcium ion binding
cellular oxidant detoxification
heme binding
metal ion binding
oxidoreductase activity
response to oxidative stress
superoxide anion generation
superoxide-generating NAD(P)H oxidase activity

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InterPro
Dual oxidase, peroxidase domain
EF-Hand 1, calcium-binding site
EF-hand domain pair
EF-hand domain
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Haem peroxidase domain superfamily, animal type

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	33477	Xenbase:XB-GENE-6047411
Homo sapiens	50506	Xenbase:XB-GENE-6047411	HUMAN22838
Xenopus tropicalis	53905	Xenbase:XB-GENE-1005876
Xenopus tropicalis	79107	Xenbase:XB-GENE-6047411
Xenopus tropicalis	99439	Xenbase:XB-GENE-1005876
Xenopus tropicalis	171608	Xenbase:XB-GENE-6047411
Xenopus tropicalis	186188	Xenbase:XB-GENE-6047411
Mus musculus	214593		MOUSE32874
Xenopus tropicalis	266807	Xenbase:XB-GENE-1005876
Canis lupus familiaris	403719		CANLF12476

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Last updated: December 8, 2025