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acid sensing ion channel subunit 1

Summary

Gene Symbol

Asic1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

79123

PubChem

79123

Alliance of Genome Resources

RGD:71062

Annotation

Keyword

Alternative splicing
Calcium transport
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Sodium channel
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P55926	Amiloride-sensitive cation channel 2, neuronal Brain sodium channel 2
A6KCG6
A6KCG7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
protein homotrimerization	ISS
behavioral fear response	ISO
establishment of localization in cell	ISO
inorganic cation transmembrane transport	IDA	11448963
monoatomic cation transport	ISO

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

memory

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

associative learning

memory

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to abiotic stimulus [inference]

response to pH [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport [inference]

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell

neurotransmitter secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
cell surface	IDA	19074149
synapse	ISO
glutamatergic synapse	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

presynapse

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
monoatomic ion-gated channel activity	ISO
ion channel activity	IDA	9707631
monoatomic ion channel activity	IDA	9707631
inorganic cation transmembrane transporter activity	IDA	11448963
ligand-gated sodium channel activity	IBA IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

monoatomic ion-gated channel activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

ligand-gated sodium channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

acid-sensing ion channel 1

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 3** entries
Gene Ontology
ligand-gated sodium channel activity
sodium channel activity
sodium ion transmembrane transport

Displaying **all 3** entries
InterPro
Epithelial sodium channel, chordates
Epithelial sodium channel, conserved site
Epithelial sodium channel

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cell surface	PMID:19074149

Ortholog

Displaying entries **61 - 70** of **110** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Mandrillus leucophaeus	105528052		MANLE15682
Cercocebus atys	105580362		CERAT25144
Aotus nancymaae	105709519		AOTNA16063
Propithecus coquereli	105815806		PROCO09242
Microcebus murinus	105869826		MICMU09812
Dipodomys ordii	105987484	10020_0:001f83	DIPOR13240
Equus asinus asinus	106845033		EQUAS16772
Marmota marmota marmota	107148859	9994_0:0012dd
Rhinopithecus bieti	108543956		RHIBE25103
Crocodylus porosus	109324419		CROPO26528