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membrane bound O-acyltransferase domain containing 7

Summary

Gene Symbol

MBOAT7

Aliases

BB1
LPIAT1
LPLAT
LPLAT11
hMBOA-7
lysophosphatidylinositol acyltransferase
lysophosphatidylinositol acyltransferase 1
lysophospholipid acyltransferase 11
lysophospholipid acyltransferase 7

Organism

Homo sapiens (human)

External Links

NCBI Gene

79143

HGNC

15505

KEGG Gene ID

hsa:79143

PubChem

79143

Alliance of Genome Resources

HGNC:15505

Annotation

Keyword

3D-structure
Acyltransferase
Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Intellectual disability
Phospholipid biosynthesis
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96N66	1-acylglycerophosphatidylinositol O-acyltransferase Bladder and breast carcinoma-overexpressed gene 1 protein Leukocyte receptor cluster member 4 Lysophosphatidylinositol acyltransferase Membrane-bound O-acyltransferase domain-containing protein 7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
layer formation in cerebral cortex	ISS
lipid modification	IBA
phosphatidylcholine acyl-chain remodeling	IDA	18772128
ventricular system development	IEA
phosphatidylinositol biosynthetic process	IBA IMP	18094042

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

phosphatidylinositol metabolic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

layer formation in cerebral cortex

anatomical structure development [inference]

system development [inference]

ventricular system development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of triglyceride metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of triglyceride metabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of triglyceride metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	30959108
mitochondria-associated endoplasmic reticulum membrane	IBA IDA	23510452
endoplasmic reticulum membrane
membrane	HDA IBA	19946888

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
1-acylglycerol-3-phosphate O-acyltransferase activity
O-acyltransferase activity	IDA IMP ISS	18094042 18772128
protein binding	IPI	21903422 23510452
2-acylglycerol-3-phosphate O-acyltransferase activity
lysophospholipid acyltransferase activity	IBA ISS

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

2-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity

lysophosphatidic acid acyltransferase activity [inference]

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K13516

Name

lysophospholipid acyltransferase 7 [EC:2.3.1.-]

References

18772128

Disease

Disease Ontology

Displaying entries **1 - 10** of 53 in total

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DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060262	gallbladder disease	DisGeNET
DOID:0060810	syndromic X-linked intellectual disability type 10	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:0081219	autosomal recessive intellectual developmental disorder 57	Alliance of Genome Resources
DOID:10534	stomach cancer	DisGeNET DisGeNET
DOID:10588	adrenoleukodystrophy	DisGeNET
DOID:1059	intellectual disability	DisGeNET DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:10908	hydrocephalus	DisGeNET Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **11 - 18** of 18 in total

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HPO ID	HPO Term
HP:0002123	Generalized myoclonic seizure
HP:0002126	Polymicrogyria
HP:0002197	Generalized-onset seizure
HP:0002373	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002540	Inability to walk
HP:0003593	Infantile onset
HP:0007359	Focal-onset seizure
HP:0008936	Axial hypotonia

Displaying 1 entry
Disease ID	Disease Name
OMIM:617188	intellectual disability, autosomal recessive 57

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 57

OMIM Phenotypes

INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL RECESSIVE 57; MRT57

KEGG Diseases

Autosomal recessive intellectual developmental disorder

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	181252	WB:WBGene00008806
Drosophila melanogaster	33900	FB:FBgn0031815
Latimeria chalumnae	102360410		LATCH10327
Danio rerio	393509	ZFIN:ZDB-GENE-040426-1516	DANRE10886
Astyanax mexicanus	103043354		ASTMX10631
Ictalurus punctatus	108264261		ICTPU13308
Ictalurus punctatus	108264268		ICTPU13311
Ictalurus punctatus	108264271		ICTPU13313
Ictalurus punctatus	108264277		ICTPU13314
Electrophorus electricus	113573079		ELEEL08907

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Tools

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Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements