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5-hydroxytryptamine receptor 3A

Summary

Gene Symbol

Htr3a

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

79246

PubChem

79246

Alliance of Genome Resources

RGD:61818

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Ion channel
Ligand-gated ion channel
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A8L2Q4R5
A6J4A7
Q62999
P35563	5-hydroxytryptamine receptor 3 Serotonin receptor 3A Serotonin-gated ion channel receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
serotonin receptor signaling pathway	ISO
chemical synaptic transmission	TAS	12196560
chemical synaptic transmission	IBA
positive regulation of ion transmembrane transporter activity	IDA	10854267
monoatomic ion transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

signal transduction [inference]

serotonin receptor signaling pathway

serotonin-gated cation-selective signaling pathway

ligand-gated ion channel signaling pathway [inference]

serotonin-gated cation-selective signaling pathway

transmembrane transport [inference]

monoatomic ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

multicellular organismal process [inference]

behavior [inference]

adult behavior [inference]

behavioral response to ethanol

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to organic cyclic compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to alkaloid [inference]

response to cocaine

response to oxygen-containing compound [inference]

response to cocaine

response to alcohol [inference]

response to ethanol

response to salt [inference]

response to cocaine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

regulation of monoatomic ion transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transport [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

regulation of cellular process [inference]

signal transduction [inference]

serotonin receptor signaling pathway

serotonin-gated cation-selective signaling pathway

ligand-gated ion channel signaling pathway [inference]

serotonin-gated cation-selective signaling pathway

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of ion transmembrane transporter activity

regulation of biological quality [inference]

regulation of membrane potential

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

regulation of presynaptic membrane potential

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity

positive regulation of molecular function [inference]

positive regulation of transporter activity [inference]

positive regulation of ion transmembrane transporter activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
axon	IDA	17650111
cleavage furrow	ISO
cleavage furrow	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex [inference]

serotonin receptor complex [inference]

serotonin-activated cation-selective channel complex

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

serotonin-activated cation-selective channel complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

neurotransmitter receptor complex [inference]

serotonin-activated cation-selective channel complex

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

serotonin-activated cation-selective channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

cation channel complex [inference]

serotonin-activated cation-selective channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cleavage furrow

synaptic membrane [inference]

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

cell body [inference]

neuronal cell body

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
extracellular ligand-gated monoatomic ion channel activity	IEA
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA
serotonin-gated monoatomic cation channel activity	ISO
serotonin-gated monoatomic cation channel activity	IDA	12196560

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity

excitatory extracellular ligand-gated monoatomic ion channel activity

transmitter-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

serotonin-gated monoatomic cation channel activity

ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

binding [inference]

protein binding [inference]

identical protein binding

ion binding [inference]

cation binding [inference]

serotonin binding

amine binding [inference]

serotonin binding

organic cyclic compound binding [inference]

serotonin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

serotonin receptor activity [inference]

serotonin-gated monoatomic cation channel activity

neurotransmitter receptor activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

postsynaptic neurotransmitter receptor activity [inference]

neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential [inference]

transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acetylcholine receptor subunit alpha

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
extracellular ligand-gated monoatomic ion channel activity
ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport

Displaying **all 9** entries
InterPro
5-hydroxytryptamine 3 receptor, A subunit
5-hydroxytryptamine 3 receptor
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
axon	PMID:17650111
neuronal cell body	PMID:17650111

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3359	Xenbase:XB-GENE-990708	HUMAN09460
Mus musculus	15561	Xenbase:XB-GENE-990708	MOUSE60564
Xenopus tropicalis	79246	Xenbase:XB-GENE-990708
Xenopus tropicalis	181009	Xenbase:XB-GENE-990708
Pan troglodytes	451556		PANTR04375
Canis lupus familiaris	489399		CANLF15271
Danio rerio	571641		DANRE21280
Bos taurus	617674		BOVIN06485
Macaca mulatta	696912		MACMU11441
Oryctolagus cuniculus	100009570		RABIT00599

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OrthoDB (Group)

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