GlyCosmos Portal

Submissions

aconitase 2

Summary

Gene Symbol

Aco2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

79250

PubChem

79250

Alliance of Genome Resources

RGD:621360

Annotation

Keyword

4Fe-4S
Acetylation
Direct protein sequencing
Lyase
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9ER34	Citrate hydro-lyase
A6HT25

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
response to isolation stress	IEP	19616040
isocitrate metabolic process	IDA	14674759 9712727
tricarboxylic acid cycle	IBA IDA IEA ISO	9712727
liver development	IEP	755797
citrate metabolic process	IDA ISO	14674759 9712727

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

citrate metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

response to isolation stress

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitochondrion	IBA IEA ISO
mitochondrial matrix	ISO
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
protein binding	IPI	15840721
aconitate hydratase activity	IBA IDA IEA ISO	12139479 14674759 9712727
metal ion binding	IEA
4 iron, 4 sulfur cluster binding	IBA IDA IEA	14674759
iron ion binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

aconitate hydratase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

Aconitase

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
K: Transcription

Displaying **all 5** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
iron-sulfur cluster binding
lyase activity
metal ion binding
tricarboxylic acid cycle

Displaying **all 8** entries
InterPro
Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
Aconitase family, 4Fe-4S cluster binding site
Aconitase, domain 2
Aconitase, iron-sulfur domain
Aconitase, mitochondrial-like
Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
Aconitase/3-isopropylmalate dehydratase, swivel

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0050883	infantile cerebellar-retinal degeneration	Alliance of Genome Resources
DOID:0111442	optic atrophy 9	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1891	optic nerve disease	Alliance of Genome Resources
DOID:331	central nervous system disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **132** in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	50		HGNC:118	HUMAN60797
Mus musculus	11429	10090_1:004716	MGI:87880	MOUSE17217
Drosophila melanogaster	41326		FB:FBgn0037862
Drosophila melanogaster	44149		FB:FBgn0010100
Caenorhabditis elegans	176121		WB:WBGene00000041
Bos taurus	280976			BOVIN30758
Danio rerio	322670		ZFIN:ZDB-GENE-030131-1390	DANRE45736
Sus scrofa	396999			PIGXX25007
Canis lupus familiaris	474487			CANLF01566
Xenopus tropicalis	496933		Xenbase:XB-GENE-1000785

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements