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aconitase 2

Summary

Gene Symbol

Aco2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

79250

PubChem

79250

Alliance of Genome Resources

RGD:621360

Annotation

Keyword

4Fe-4S
Acetylation
Direct protein sequencing
Lyase
Mitochondrion
Phosphoprotein
Reference proteome
Transit peptide
Tricarboxylic acid cycle

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9ER34	Citrate hydro-lyase
A6HT25

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
citrate metabolic process	ISO
citrate metabolic process	IDA	14674759 9712727
isocitrate metabolic process	IDA	14674759 9712727
response to isolation stress	IEP	19616040

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

citrate metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

primary metabolic process [inference]

tricarboxylic acid cycle

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

isocitrate metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

tricarboxylic acid metabolic process [inference]

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

response to isolation stress

Displaying **all 5** entries
GO Term	Evidence Code	PMID
mitochondrion	ISO
mitochondrion	IBA
mitochondrion	IEA
mitochondrial matrix	ISO
cytosol	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
aconitate hydratase activity	ISO
aconitate hydratase activity	IDA	12139479 14674759 9712727
aconitate hydratase activity	IBA
aconitate hydratase activity	IEA
iron ion binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

lyase activity [inference]

carbon-oxygen lyase activity [inference]

hydro-lyase activity [inference]

aconitate hydratase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ACONITATE HYDRATASE

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
4 iron, 4 sulfur cluster binding
iron-sulfur cluster binding
lyase activity
metal ion binding
tricarboxylic acid cycle

Displaying **all 8** entries
InterPro
Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
Aconitase family, 4Fe-4S cluster binding site
Aconitase, domain 2
Aconitase, iron-sulfur domain
Aconitase, mitochondrial-like
Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
Aconitase/3-isopropylmalate dehydratase, swivel