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steroid 5 alpha-reductase 3

Summary

Gene Symbol

SRD5A3

Aliases

3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+))
FLJ13352
SRD5A2L
SRD5A2L1
polyprenol reductase

Organism

Homo sapiens (human)

External Links

NCBI Gene

79644

HGNC

25812

KEGG Gene ID

hsa:79644

PubChem

79644

Alliance of Genome Resources

HGNC:25812

Annotation

Keyword

Cataract
Congenital disorder of glycosylation
Endoplasmic reticulum
Intellectual disability
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H8P0	3-oxo-5-alpha-steroid 4-dehydrogenase 3 Steroid 5-alpha-reductase 2-like Steroid 5-alpha-reductase 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
dolichol-linked oligosaccharide biosynthetic process	IMP	20637498
dolichol-linked oligosaccharide biosynthetic process	IBA
dolichyl diphosphate biosynthetic process	TAS
androgen biosynthetic process	TAS
polyprenol catabolic process	IDA	20637498

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

biosynthetic process [inference]

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

androgen metabolic process [inference]

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

alcohol catabolic process [inference]

polyprenol catabolic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

androgen metabolic process [inference]

androgen biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

androgen metabolic process [inference]

androgen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

steroid hormone biosynthetic process [inference]

androgen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

alcohol catabolic process [inference]

polyprenol catabolic process

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyprenol catabolic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

cellular lipid metabolic process [inference]

oligosaccharide-lipid intermediate biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

phospholipid metabolic process [inference]

phospholipid biosynthetic process [inference]

dolichyl diphosphate biosynthetic process

dolichyl diphosphate metabolic process [inference]

dolichyl diphosphate biosynthetic process

isoprenoid metabolic process [inference]

isoprenoid biosynthetic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

isoprenoid catabolic process [inference]

polyprenol catabolic process

polyprenol metabolic process [inference]

polyprenol biosynthetic process [inference]

dolichol biosynthetic process

polyprenol catabolic process

dolichol metabolic process

cellular lipid catabolic process [inference]

isoprenoid catabolic process [inference]

polyprenol catabolic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process [inference]

androgen biosynthetic process

hormone biosynthetic process [inference]

androgen biosynthetic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA	20637498
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	20637498

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
3-oxo-5-alpha-steroid 4-dehydrogenase activity	TAS
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	TAS
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IDA	20637498
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)	IDA	17986282
polyprenol reductase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

enone reductase activity [inference]

3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)

polyprenol reductase activity

steroid dehydrogenase activity, acting on the CH-CH group of donors [inference]

3-oxo-5-alpha-steroid 4-dehydrogenase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

3-oxo-5-alpha-steroid 4-dehydrogenase 3

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
3-oxo-5-alpha-steroid 4-dehydrogenase activity
dolichol biosynthetic process
dolichol metabolic process
dolichol-linked oligosaccharide biosynthetic process
lipid metabolic process
oxidoreductase activity, acting on the CH-CH group of donors
oxidoreductase activity
polyprenol catabolic process
polyprenol reductase activity

Displaying **all 2** entries
InterPro
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Polyprenol reductase

KEGG BRITE Database

Orthology

K12345

Name

3-oxo-5-alpha-steroid 4-dehydrogenase 3 / polyprenol reductase [EC:1.3.1.22 1.3.1.94]

References

20637498

Rhea

RHEA:34279

NADP⁺

H⁺ + NADPH

Enzyme

1.3.1.94

PMID

RHEA:21952

5α-pregnane-3,20-dione + NADP⁺

H⁺ + progesterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:50820

17β-hydroxy-5α-androstan-3-one + NADP⁺

H⁺ + testosterone + NADPH

Enzyme

1.3.1.22

PMID

RHEA:54384

a 3-oxo-5α-steroid + NADP⁺

H⁺ + a 3-oxo-Δ⁴-steroid + NADPH

Enzyme

1.3.1.22

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050807	Kahrizi syndrome	Alliance of Genome Resources
DOID:0080568	congenital disorder of glycosylation Iq	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 64 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000248	Brachycephaly
HP:0000316	Hypertelorism
HP:0000329	Facial hemangioma
HP:0000365	Hearing impairment
HP:0000369	Low-set ears
HP:0000414	Bulbous nose
HP:0000431	Wide nasal bridge
HP:0000510	Rod-cone dystrophy
HP:0000518	Cataract

Displaying **all 3** entries
Disease ID	Disease Name
OMIM:612379	SRD5A3-congenital disorder of glycosylation
OMIM:612713	Kahrizi syndrome
ORPHA:324737	SRD5A3-congenital disorder of glycosylation

PubChem Disease

GHR Health Conditions

SRD5A3-congenital disorder of glycosylation

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Congenital disorders of glycosylation type I

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003856
Gene Name: steroid 5 alpha-reductase 3

Ortholog

Displaying entries **1 - 10** of 65 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	57357		MOUSE44181
Xenopus tropicalis	79644	Xenbase:XB-GENE-985511
Rattus norvegicus	305291		RATNO07769
Pan troglodytes	471241		PANTR33958
Bos taurus	535834		BOVIN31500
Danio rerio	560717		DANRE19475
Macaca mulatta	696381		MACMU36210
Monodelphis domestica	100017228		MONDO27291
Equus caballus	100059506		HORSE30155
Equus caballus	100059582		HORSE30155

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements