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cleavage and polyadenylation specific factor 7

Summary

Gene Symbol

CPSF7

Organism

Homo sapiens (human)

External Links

NCBI Gene

79869

PubChem

79869

Alliance of Genome Resources

HGNC:30098

Annotation

Keyword

3D-structure
Alternative splicing
Cytoplasm
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Ubl conjugation
mRNA processing

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8N684	Cleavage and polyadenylation specificity factor 59 kDa subunit Cleavage factor Im complex 59 kDa subunit Pre-mRNA cleavage factor Im 59 kDa subunit
B4DGF8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
mRNA 3'-end processing	IDA	20695905
protein tetramerization	IDA	20695905
protein heterotetramerization	IDA	23187700
mRNA alternative polyadenylation	IMP	20695905 29276085
mRNA alternative polyadenylation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA 3'-end processing

RNA 3'-end processing [inference]

mRNA 3'-end processing

co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway [inference]

co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA 3'-end processing

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein tetramerization

protein heterotetramerization

protein heterooligomerization [inference]

protein heterotetramerization

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	19864460 20695905
nucleoplasm	TAS
cytoplasm	IDA	19864460
mRNA cleavage and polyadenylation specificity factor complex	IDA	23187700
mRNA cleavage and polyadenylation specificity factor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex

mRNA cleavage and polyadenylation specificity factor complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
mRNA binding	IBA
protein binding	IPI	16189514 16713569 17024186 20695905 25416956 25910212 26496610 26871637 29276085 32296183 32814053 39251607

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cleavage and polyadenylation specificity factor

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
mRNA alternative polyadenylation

Displaying **all 4** entries
InterPro
CPSF6/7 family
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 55 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	11052	WB:WBGene00008362
Xenopus tropicalis	79869	Xenbase:XB-GENE-5754390
Mus musculus	269061		MOUSE26051
Rattus norvegicus	365407		RATNO20026
Caenorhabditis elegans	432508	WB:WBGene00008362
Pan troglodytes	451237		PANTR03078
Canis lupus familiaris	476066		CANLF06198
Macaca mulatta	693730		MACMU09352
Monodelphis domestica	100027234		MONDO26843
Ornithorhynchus anatinus	100088460		ORNAN17606