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glycine receptor alpha 3

Summary

Gene Symbol

GLRA3

Organism

Homo sapiens (human)

External Links

NCBI Gene

8001

PubChem

8001

Alliance of Genome Resources

HGNC:4328

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Cell projection
Chloride channel
Disulfide bond
Glycoprotein
Ligand-gated ion channel
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Receptor
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
O75311
Q9UPF3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein homooligomerization	IDA	26416729
excitatory postsynaptic potential	IEA
chloride transmembrane transport	IDA	9677400
chloride transmembrane transport	IBA

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential [inference]

regulation of postsynaptic membrane potential [inference]

excitatory postsynaptic potential

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	26416729
plasma membrane	IMP	9677400
glycine-gated chloride channel complex	IDA	9677400
dendrite	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

glycine-gated chloride channel complex

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex [inference]

glycine-gated chloride channel complex

transporter complex [inference]

transmembrane transporter complex

monoatomic ion channel complex [inference]

chloride channel complex [inference]

glycine-gated chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
excitatory extracellular ligand-gated monoatomic ion channel activity	IBA
chloride channel activity	IBA
protein binding	IPI	28514442 33961781
glycine binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

glycine-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

ligand-gated monoatomic anion channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

glycine-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

extracellular ligand-gated monoatomic ion channel activity [inference]

excitatory extracellular ligand-gated monoatomic ion channel activity

extracellularly glycine-gated ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

inhibitory extracellular ligand-gated monoatomic ion channel activity [inference]

extracellularly glycine-gated chloride channel activity

transmitter-gated monoatomic ion channel activity [inference]

glycine-gated chloride ion channel activity

ligand-gated monoatomic anion channel activity [inference]

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glycine-gated chloride ion channel activity

salt transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

binding [inference]

protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glycine binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

amino acid binding [inference]

glycine binding

cation binding [inference]

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

neurotransmitter receptor activity

transmitter-gated channel activity [inference]

transmitter-gated monoatomic ion channel activity [inference]

glycine-gated chloride ion channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

gamma-aminobutyric acid receptor

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 7** entries
Gene Ontology
chloride channel activity
chloride transmembrane transport
excitatory extracellular ligand-gated monoatomic ion channel activity
extracellular ligand-gated monoatomic ion channel activity
monoatomic ion channel activity
monoatomic ion transport
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Displaying **all 8** entries
InterPro
Gamma-aminobutyric acid A receptor/Glycine receptor alpha
Neuronal acetylcholine receptor
Neurotransmitter-gated ion-channel ligand-binding domain superfamily
Neurotransmitter-gated ion-channel ligand-binding domain
Neurotransmitter-gated ion-channel transmembrane domain superfamily
Neurotransmitter-gated ion-channel transmembrane domain
Neurotransmitter-gated ion-channel, conserved site
Neurotransmitter-gated ion-channel

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	2741	FB:FBgn0024963
Drosophila melanogaster	2742	FB:FBgn0024963
Drosophila melanogaster	2743	FB:FBgn0024963
Xenopus tropicalis	8001	Xenbase:XB-GENE-1011160
Drosophila melanogaster	14654	FB:FBgn0024963
Drosophila melanogaster	14657	FB:FBgn0024963
Drosophila melanogaster	14658	FB:FBgn0024963
Drosophila melanogaster	24397	FB:FBgn0024963
Drosophila melanogaster	25456	FB:FBgn0024963
Drosophila melanogaster	25674	FB:FBgn0024963