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MIRAGE

semaphorin 6D

Summary

Gene Symbol

SEMA6D

Organism

Homo sapiens (human)

External Links

NCBI Gene

80031

PubChem

80031

Alliance of Genome Resources

HGNC:16770

Annotation

Keyword

Alternative splicing
Cell membrane
Cytoplasm
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Neurogenesis
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8NFY4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 12** of 12 in total

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GO Term	Evidence Code	PMID
semaphorin-plexin signaling pathway	ISS
semaphorin-plexin signaling pathway	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

muscle cell migration [inference]

smooth muscle cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

developmental process [inference]

anatomical structure development [inference]

system development [inference]

ventricular system development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of developmental growth [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of smooth muscle cell migration [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of smooth muscle cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of smooth muscle cell migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IMP	12110693
Golgi apparatus	IDA
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
semaphorin receptor binding	IBA
chemorepellent activity	IBA
receptor ligand activity	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

semaphorin receptor binding

receptor ligand activity

chemorepellent activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

semaphorin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
chemorepellent activity
negative regulation of axon extension involved in axon guidance
neural crest cell migration
positive regulation of cell migration
semaphorin receptor binding
semaphorin-plexin signaling pathway

Displaying **all 5** entries
InterPro
PSI domain
Sema domain superfamily
Sema domain
Semaphorin
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **91 - 100** of **129** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Nannospalax galili	103747023		NANGA09370
Serinus canaria	103816011		SERCA10324
Rhinopithecus roxellana	104657952		RHIRO15659
Pteropus vampyrus	105288807		PTEVA11871
Macaca nemestrina	105490833		MACNE04008
Mandrillus leucophaeus	105529980		MANLE24225
Cercocebus atys	105588193		CERAT31211
Aotus nancymaae	105710088		AOTNA14541
Propithecus coquereli	105814265		PROCO01822
Microcebus murinus	105870742		MICMU15070

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Last updated: March 31, 2025