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post-GPI attachment to proteins inositol deacylase 1

Summary

Gene Symbol

PGAP1

Aliases

Bst1
FLJ12377
GPI inositol-deacylase
SPG67

Organism

Homo sapiens (human)

External Links

NCBI Gene

80055

HGNC

25712

KEGG Gene ID

hsa:80055

PubChem

80055

Alliance of Genome Resources

HGNC:25712

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Hydrolase
Intellectual disability
Protein transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q75T13	Post-GPI attachment to proteins factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
positive regulation of ER to Golgi vesicle-mediated transport	ISS
embryonic pattern specification	IEA
sensory perception of sound	IEA
GPI anchor metabolic process	IBA
anterior/posterior axis specification	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

macromolecule modification [inference]

protein modification process [inference]

attachment of GPI anchor to protein

carbohydrate derivative metabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

pattern specification process [inference]

regionalization [inference]

forebrain regionalization

axis specification [inference]

anterior/posterior axis specification

embryonic pattern specification

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA ISS
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidylinositol deacylase activity	IBA ISS
hydrolase activity, acting on ester bonds

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

phosphatidylinositol deacylase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K05294

Name

GPI inositol-deacylase [EC:3.-.-.-]

References

14734546

Disease

Disease Ontology

Displaying entries **31 - 34** of 34 in total

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DO ID	Disease Name	Source
DOID:936	brain disease	DisGeNET
DOID:9521	Laron syndrome	DisGeNET
DOID:9854	lingual-facial-buccal dyskinesia	DisGeNET
DOID:9923	developmental coordination disorder	DisGeNET

The Human Phenotype Ontology

Displaying entries **51 - 60** of 65 in total

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HPO ID	HPO Term
HP:0006297	Enamel hypoplasia
HP:0006817	Aplasia/Hypoplasia of the cerebellar vermis
HP:0006934	Congenital nystagmus
HP:0007020	Progressive spastic paraplegia
HP:0008936	Axial hypotonia
HP:0010864	Intellectual disability, severe
HP:0011463	Childhood onset
HP:0011471	Gastrostomy tube feeding in infancy
HP:0011968	Feeding difficulties
HP:0012447	Abnormal myelination

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:615802	intellectual disability, autosomal recessive 42
ORPHA:401820	autosomal recessive spastic paraplegia type 67

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 42

OMIM Phenotypes

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FEATURES, SPASTICITY, AND BRAIN ABNORMALITIES; NEDDSBA

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006714
Gene Name: post-GPI attachment to proteins 1

Ortholog

Displaying entries **41 - 50** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cricetulus griseus	100761032		CRIGR24808
Mus musculus	241062	MGI:2443342	MOUSE28128
Rattus norvegicus	316400	RGD:1303213	RATNO42385
Cavia porcellus	100724070		CAVPO22024
Octodon degus	101577525		OCTDE06204
Monodelphis domestica	100029599		MONDO23172
Anolis carolinensis	100561975		ANOCA16028
Ursus maritimus	103659703		URSMA01378
Vombatus ursinus	114045794		VOMUR02975
Bos indicus x Bos taurus	113905745		BOBOX37449

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

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Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements