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post-GPI attachment to proteins inositol deacylase 1

Summary

Gene Symbol

PGAP1

Aliases

Bst1
FLJ12377
GPI inositol-deacylase
SPG67

Organism

Homo sapiens (human)

External Links

NCBI Gene

80055

HGNC

25712

KEGG Gene ID

hsa:80055

PubChem

80055

Alliance of Genome Resources

HGNC:25712

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Hydrolase
Intellectual disability
Protein transport
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q75T13	Post-GPI attachment to proteins factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
positive regulation of ER to Golgi vesicle-mediated transport	ISS
embryonic pattern specification	IEA
sensory perception of sound	IEA
GPI anchor metabolic process	IBA
anterior/posterior axis specification	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

macromolecule modification [inference]

protein modification process [inference]

attachment of GPI anchor to protein

carbohydrate derivative metabolic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

attachment of GPI anchor to protein

cellular process [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

pattern specification process [inference]

regionalization [inference]

forebrain regionalization

axis specification [inference]

anterior/posterior axis specification

embryonic pattern specification

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular localization [inference]

intracellular transport [inference]

endoplasmic reticulum to Golgi vesicle-mediated transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA ISS
endoplasmic reticulum membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidylinositol deacylase activity	IBA ISS
hydrolase activity, acting on ester bonds

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

phosphatidylinositol deacylase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K05294

Name

GPI inositol-deacylase [EC:3.-.-.-]

References

14734546

Disease

Disease Ontology

Displaying entries **1 - 10** of 34 in total

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DO ID	Disease Name	Source
DOID:0060284	paroxysmal nocturnal hemoglobinuria	DisGeNET
DOID:0060308	autosomal recessive intellectual developmental disorder	DisGeNET
DOID:0060810	syndromic X-linked intellectual disability type 10	DisGeNET
DOID:0060823	syndromic X-linked intellectual disability 94	DisGeNET
DOID:0110881	holoprosencephaly 1	DisGeNET
DOID:1059	intellectual disability	DisGeNET
DOID:10907	microcephaly	DisGeNET
DOID:11832	visual epilepsy	DisGeNET DisGeNET
DOID:12139	dysthymic disorder	DisGeNET
DOID:12859	choreatic disease	DisGeNET

The Human Phenotype Ontology

Displaying entries **1 - 10** of 65 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000154	Wide mouth
HP:0000164	Abnormality of the dentition
HP:0000193	Bifid uvula
HP:0000252	Microcephaly
HP:0000294	Low anterior hairline
HP:0000395	Prominent antihelix
HP:0000400	Macrotia
HP:0000470	Short neck
HP:0000490	Deeply set eye

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:615802	intellectual disability, autosomal recessive 42
ORPHA:401820	autosomal recessive spastic paraplegia type 67

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 42

OMIM Phenotypes

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FEATURES, SPASTICITY, AND BRAIN ABNORMALITIES; NEDDSBA

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006714
Gene Name: post-GPI attachment to proteins 1

Ortholog

Displaying entries **11 - 20** of 70 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Astatotilapia calliptera	113007935		ASTCA13198
Sparus aurata	115587832		SPAAU27955
Xenopus laevis	447534	Xenbase:XB-GENE-5818693
Chrysemys picta bellii	101946941		CHRPI22636
Cercocebus atys	105579987		CERAT00374
Macaca fascicularis	102139883		MACFA05666
Macaca mulatta	696475		MACMU05679
Macaca nemestrina	105468162		MACNE08816
Papio anubis	101018135		PAPAN01368
Mandrillus leucophaeus	105551792		MANLE26474

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements