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valosin containing protein interacting protein 1

Summary

Gene Symbol

VCPIP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

80124

PubChem

80124

Alliance of Genome Resources

HGNC:30897

Annotation

Keyword

Acetylation
Cytoplasm
DNA repair
Endoplasmic reticulum
Golgi apparatus
Nucleus
Phosphoprotein
Reference proteome
Thiol protease
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96JH7	Valosin-containing protein p97/p47 complex-interacting protein 1 Valosin-containing protein p97/p47 complex-interacting protein p135

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 11 in total

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GO Term	Evidence Code	PMID
DNA damage response	IDA	32649882
protein K11-linked deubiquitination	IDA	23827681
cellular response to DNA damage stimulus	IDA	32649882
protein-DNA covalent cross-linking repair	IBA IDA	32649882
regulation of protein localization to chromatin	IDA	32649882

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein modification by small protein removal [inference]

protein deubiquitination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein modification by small protein removal [inference]

protein deubiquitination

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein modification by small protein removal [inference]

protein deubiquitination

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

protein-DNA covalent cross-linking repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

protein-DNA covalent cross-linking repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization [inference]

endoplasmic reticulum membrane fusion

Golgi organization [inference]

Golgi reassembly

organelle fusion [inference]

organelle membrane fusion [inference]

endoplasmic reticulum membrane fusion

cellular component assembly [inference]

Golgi reassembly

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

endoplasmic reticulum membrane fusion

endoplasmic reticulum membrane organization [inference]

endoplasmic reticulum membrane fusion

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

protein-DNA covalent cross-linking repair

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair [inference]

protein-DNA covalent cross-linking repair

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to chromatin

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of protein localization to chromatin

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum lumen	TAS
Golgi stack	IEA
nucleus	IDA	32649882
cytoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

Golgi stack

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 33961781
cysteine-type deubiquitinase activity	IBA IDA ISS	23827681 32649882

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

cysteine-type deubiquitinase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Deubiquitinating protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Golgi reassembly
endoplasmic reticulum membrane fusion
hydrolase activity
protein ubiquitination

Displaying **all 5** entries
InterPro
Deubiquitinating protein VCPIP1, N-terminal
Deubiquitinating protein VCPIP1
OTU domain
OTU1, Ubl domain
Ubiquitin-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3911	progeria	Alliance of Genome Resources

Ortholog

Displaying entries **101 - 103** of **103** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Panthera leo	122210481			PANLE18949
Ursus americanus	123786686			URSAM16568
Pongo pygmaeus	129042000	9600_0:002382

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024