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SPG11 vesicle trafficking associated, spatacsin

Summary

Gene Symbol

SPG11

Organism

Homo sapiens (human)

External Links

NCBI Gene

80208

PubChem

80208

Alliance of Genome Resources

HGNC:11226

Annotation

Keyword

Alternative splicing
Amyotrophic lateral sclerosis
Cell projection
Charcot-Marie-Tooth disease
Cytoplasm
Hereditary spastic paraplegia
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96JI7	Colorectal carcinoma-associated protein Spastic paraplegia 11 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
protein import into nucleus	IEA
lysosome organization	IDA	25365221
chemical synaptic transmission	IMP	24794856
chemical synaptic transmission	IBA
axonogenesis	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

synaptic vesicle transport

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

localization within membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

autophagosome organization

vesicle organization [inference]

vesicle fusion [inference]

phagosome-lysosome fusion [inference]

phagosome-lysosome fusion involved in apoptotic cell clearance

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion [inference]

phagosome-lysosome fusion involved in apoptotic cell clearance

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

corticospinal tract morphogenesis

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion [inference]

phagosome-lysosome fusion involved in apoptotic cell clearance

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

locomotory behavior [inference]

walking behavior

motor behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

corticospinal tract morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

synaptic vesicle transport

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

synaptic vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

localization within membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of store-operated calcium entry

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleolus	IDA
cytoplasm	IDA	21545838
cytoplasm	IBA
lysosomal membrane	HDA	17897319
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20613862 25416956 29949766 36096339 37871017
protein kinase binding	IDA	25365221

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

spatacsin

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
axo-dendritic transport
chemical synaptic transmission

Displaying **all 2** entries
InterPro
Spatacsin, C-terminal domain
Spatacsin

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060197	amyotrophic lateral sclerosis type 5	Alliance of Genome Resources
DOID:0110176	Charcot-Marie-Tooth disease axonal type 2X	Alliance of Genome Resources
DOID:0110764	hereditary spastic paraplegia 11	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	80208	Xenbase:XB-GENE-5868352
Mus musculus	214585		MOUSE32836
Rattus norvegicus	311372		RATNO27335
Pan troglodytes	453391		PANTR10204
Macaca mulatta	712221		MACMU40462
Monodelphis domestica	100012368		MONDO05134
Equus caballus	100070629		HORSE16808
Ornithorhynchus anatinus	100082624		ORNAN26532
Taeniopygia guttata	100219349		TAEGU02450
Oryctolagus cuniculus	100357157		RABIT06107

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Acknowledgements