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SPG11 vesicle trafficking associated, spatacsin

Summary

Gene Symbol

SPG11

Organism

Homo sapiens (human)

External Links

NCBI Gene

80208

PubChem

80208

Alliance of Genome Resources

HGNC:11226

JoGo

SPG11

TogoVar

SPG11

Annotation

Keyword

3D-structure
Alternative splicing
Amyotrophic lateral sclerosis
Cell projection
Charcot-Marie-Tooth disease
Cytoplasm
Hereditary spastic paraplegia
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A804HID9
Q96JI7	Colorectal carcinoma-associated protein Spastic paraplegia 11 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
protein import into nucleus	IEA
lysosome organization	IDA	25365221
chemical synaptic transmission	IMP	24794856
chemical synaptic transmission	IBA
axonogenesis	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

synaptic vesicle transport

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

localization within membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

autophagosome organization

vesicle organization [inference]

vesicle fusion [inference]

phagosome-lysosome fusion [inference]

phagosome-lysosome fusion involved in apoptotic cell clearance

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion [inference]

phagosome-lysosome fusion involved in apoptotic cell clearance

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

corticospinal tract morphogenesis

cell junction organization [inference]

synapse organization [inference]

neuromuscular junction development

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

phagosome-lysosome fusion [inference]

phagosome-lysosome fusion involved in apoptotic cell clearance

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

locomotory behavior [inference]

walking behavior

motor behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

central nervous system neuron axonogenesis [inference]

central nervous system projection neuron axonogenesis [inference]

corticospinal tract morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

synaptic vesicle transport

organic substance transport [inference]

lipid transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

organic hydroxy compound transport [inference]

sterol transport [inference]

cholesterol transport [inference]

cholesterol efflux

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule

organelle localization [inference]

vesicle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

synaptic vesicle localization [inference]

synaptic vesicle transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

synaptic vesicle transport

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

organelle transport along microtubule [inference]

vesicle transport along microtubule

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport

organelle transport along microtubule [inference]

vesicle transport along microtubule

vesicle cytoskeletal trafficking [inference]

vesicle transport along microtubule

nuclear transport [inference]

nucleocytoplasmic transport [inference]

import into nucleus [inference]

protein import into nucleus

localization within membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of store-operated calcium entry

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleolus	IDA
cytoplasm	IDA	21545838
cytoplasm	IBA
lysosomal membrane	HDA	17897319
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	20613862 25416956 29949766 36096339 37871017
protein kinase binding	IDA	25365221

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060197	amyotrophic lateral sclerosis type 5	Alliance of Genome Resources
DOID:0110176	Charcot-Marie-Tooth disease axonal type 2X	Alliance of Genome Resources
DOID:0110764	hereditary spastic paraplegia 11	Alliance of Genome Resources

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Acknowledgements