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tankyrase 2
Summary
- Gene Symbol
-
- TNKS2
- Aliases
-
- ARTD6
- PARP-5b
- PARP-5c
- PARP5B
- PARP5C
- TANK2
- TNKL
- TRF1-interacting ankyrin-related ADP-ribose polymerase 2
- pART6
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ADP-ribosylation
- ANK repeat
- Cytoplasm
- Glycosyltransferase
- Golgi apparatus
- Hydroxylation
- Membrane
- Metal-binding
- NAD
- Nucleotidyltransferase
- Nucleus
- Reference proteome
- Repeat
- Telomere
- Ubl conjugation
- Wnt signaling pathway
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9H2K2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein poly-ADP-ribosylation | ||
| positive regulation of telomere maintenance via telomerase | ||
| positive regulation of telomere capping | ||
| protein auto-ADP-ribosylation | ||
| Wnt signaling pathway |
GO Hierarchy
biological process
metabolic process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of primary metabolic process [inference]
positive regulation of biological process [inference]
negative regulation of biological process [inference]
regulation of cellular process [inference]
regulation of cellular metabolic process [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| NAD+ ADP-ribosyltransferase activity | ||
| NAD+-protein ADP-ribosyltransferase activity | ||
| enzyme binding | ||
| metal ion binding | ||
| nucleotidyltransferase activity |
GO Hierarchy
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060895 | Parkinson's disease 4 | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0060891 | Parkinson's disease 19A | |
| DOID:0060896 | Parkinson's disease 23 | |
| DOID:1324 | lung cancer | |
| DOID:1325 | bronchus cancer | |
| DOID:1380 | endometrial cancer | |
| DOID:14330 | Parkinson's disease | |
| DOID:1470 | major depressive disorder | |
| DOID:1595 | melancholic depression |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 105550837 | MANLE38485 | ||
| 101139351 | GORGO01119 | ||
| 100984841 | PANPA05141 | ||
| 100609110 | PANTR01139 | ||
| 100432166 | PONAB01208 | ||
| 112913786 | VULVU00562 | ||
| 123800270 | URSAM15598 | ||
| 100464558 | AILME16010 | ||
| 101676482 | MUSPF14813 | ||
| 122201631 | PANLE03344 |
