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cubilin

Summary

Gene Symbol

Cubn

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

80848

PubChem

80848

Alliance of Genome Resources

RGD:68355

Annotation

Keyword

Calcium
Cell membrane
Cholesterol metabolism
Cleavage on pair of basic residues
Cobalamin
Coiled coil
Direct protein sequencing
Disulfide bond
EGF-like domain
Endosome
Glycoprotein
Lysosome
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0G2K9R4	Intrinsic factor-cobalamin receptor
O70244	460 kDa receptor Glycoprotein 280 Intrinsic factor-cobalamin receptor Intrinsic factor-vitamin B12 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 21 in total

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GO Term	Evidence Code	PMID
response to nutrient	IMP	15616221
cholesterol metabolic process	IEA
cobalamin metabolic process	ISO
cobalamin metabolic process	IEA
response to bacterium	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to chemical [inference]

response to nutrient

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

vitamin transport [inference]

cobalamin transport

organic substance transport [inference]

protein transport

cobalamin transport

nitrogen compound transport [inference]

protein transport

cobalamin transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
lysosomal membrane	IEA
endosome	ISO
endosome	IEA
endoplasmic reticulum	ISO

GO Hierarchy

cellular component

protein-containing complex

receptor complex

cellular anatomical entity [inference]

cytoplasm

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

plasma membrane region [inference]

cell projection membrane [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

apical part of cell

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	12724130
hemoglobin binding	IDA	11805171
cobalamin binding	IEA
cargo receptor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

hemoglobin binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

cargo receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
endocytic vesicle membrane	PMID:15578272
Golgi-associated vesicle	PMID:14576052
protein-containing complex	PMID:17990981
brush border membrane	PMID:17990981
lysosomal lumen	PMID:15578272

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements