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endoplasmic reticulum aminopeptidase 1

Summary

Gene Symbol

Erap1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

80898

PubChem

80898

Alliance of Genome Resources

MGI:1933403

Annotation

Keyword

Adaptive immunity
Aminopeptidase
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9EQH2	ARTS-1 Adipocyte-derived leucine aminopeptidase Aminopeptidase PILS Puromycin-insensitive leucyl-specific aminopeptidase VEGF-induced aminopeptidase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
peptide catabolic process	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organonitrogen compound catabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organonitrogen compound catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IBA
endoplasmic reticulum membrane	IEA
endoplasmic reticulum lumen	ISO
extracellular region	ISO ISS
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
peptidase activity	IMP	23610143
metalloaminopeptidase activity	IBA
peptide binding	IBA
interleukin-6 receptor binding	ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity

metalloaminopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-6 receptor binding

tumor necrosis factor receptor superfamily binding [inference]

tumor necrosis factor receptor binding

growth factor receptor binding [inference]

interleukin-6 receptor binding

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

endoplasmic reticulum aminopeptidase 1

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
ERAP1-like C-terminal domain
Peptidase M1, membrane alanine aminopeptidase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:13129	severe pre-eclampsia	Alliance of Genome Resources
DOID:2871	endometrial carcinoma	Alliance of Genome Resources
DOID:2893	cervix carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Aotus nancymaae	105707067		AOTNA41579
Propithecus coquereli	105805847		PROCO16314
Microcebus murinus	105876145		MICMU10450
Dipodomys ordii	105989822	10020_0:002692	DIPOR11424
Salmo salar	106570844		SALSA38354
Equus asinus asinus	106847799		EQUAS05251
Marmota marmota marmota	107140659	9994_0:00252f
Sinocyclocheilus grahami	107548995		SINGR68725
Ictalurus punctatus	108255537		ICTPU17690
Ictalurus punctatus	108255538		ICTPU17686

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements