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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
endoplasmic reticulum aminopeptidase 1
Summary
- Gene Symbol
-
- Erap1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Adaptive immunity
- Aminopeptidase
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9EQH2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| positive regulation of angiogenesis | ||
| adaptive immune response | ||
| protein catabolic process | ||
| membrane protein ectodomain proteolysis |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum lumen | ||
| extracellular region | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| peptidase activity | ||
| metalloaminopeptidase activity | ||
| peptide binding | ||
| interleukin-6 receptor binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- endoplasmic reticulum aminopeptidase 1
- Functional Category
-
- E: Amino acid transport and metabolism
- T: Signal transduction mechanisms
- U: Intracellular trafficking, secretion, and vesicular transport
| Gene Ontology |
|---|
| aminopeptidase activity |
| hydrolase activity |
| metal ion binding |
| metalloaminopeptidase activity |
| metallopeptidase activity |
| peptide binding |
| peptide catabolic process |
| proteolysis |
| zinc ion binding |
| InterPro |
|---|
| ERAP1-like C-terminal domain |
| Peptidase M1, membrane alanine aminopeptidase |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13129 | severe pre-eclampsia | |
| DOID:2871 | endometrial carcinoma | |
| DOID:2893 | cervix carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 699996 | MACMU39378 | |||
| 854669 | SGD:S000001399 | |||
| 100010465 | MONDO18574 | |||
| 100073224 | HORSE08323 | |||
| 100081570 | ORNAN12649 | |||
| 100173512 | PONAB30146 | |||
| 100352256 | RABIT01809 | |||
| 100391536 | CALJA25822 | |||
| 100496768 | Xenbase:XB-GENE-983344 | |||
| 100523953 | PIGXX19461 |
