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endoplasmic reticulum aminopeptidase 1

Summary

Gene Symbol

Erap1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

80898

PubChem

80898

Alliance of Genome Resources

MGI:1933403

Annotation

Keyword

Adaptive immunity
Aminopeptidase
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Signal-anchor
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9EQH2	ARTS-1 Adipocyte-derived leucine aminopeptidase Aminopeptidase PILS Puromycin-insensitive leucyl-specific aminopeptidase VEGF-induced aminopeptidase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	IBA IDA	23610143
positive regulation of angiogenesis	IMP	11964289
adaptive immune response	IEA
protein catabolic process	ISO
membrane protein ectodomain proteolysis	ISO ISS

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organonitrogen compound catabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide catabolic process

protein metabolic process [inference]

proteolysis

membrane protein proteolysis [inference]

membrane protein ectodomain proteolysis

protein catabolic process

organonitrogen compound catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

peptide catabolic process

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IBA
endoplasmic reticulum membrane	IEA
endoplasmic reticulum lumen	ISO
extracellular region	ISO ISS
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
peptidase activity	IMP	23610143
metalloaminopeptidase activity	IBA
peptide binding	IBA
interleukin-6 receptor binding	ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity

metalloaminopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

metallopeptidase activity [inference]

metalloexopeptidase activity

metalloaminopeptidase activity

exopeptidase activity [inference]

aminopeptidase activity

metalloaminopeptidase activity

metalloexopeptidase activity

metalloaminopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-6 receptor binding

tumor necrosis factor receptor superfamily binding [inference]

tumor necrosis factor receptor binding

growth factor receptor binding [inference]

interleukin-6 receptor binding

amide binding [inference]

peptide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

endoplasmic reticulum aminopeptidase 1

Functional Category

E: Amino acid transport and metabolism
T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying **all 9** entries
Gene Ontology
aminopeptidase activity
hydrolase activity
metal ion binding
metalloaminopeptidase activity
metallopeptidase activity
peptide binding
peptide catabolic process
proteolysis
zinc ion binding

Displaying **all 2** entries
InterPro
ERAP1-like C-terminal domain
Peptidase M1, membrane alanine aminopeptidase

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:13129	severe pre-eclampsia	Alliance of Genome Resources
DOID:2871	endometrial carcinoma	Alliance of Genome Resources
DOID:2893	cervix carcinoma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Ictidomys tridecemlineatus	101970056	43179_0:003fd2	ICTTR04970
Microtus ochrogaster	102002763	79684_0:002626
Chinchilla lanigera	102010260	34839_0:001267	CHILA05763
Macaca fascicularis	102146570		MACFA35964
Capra hircus	102185179		CAPHI26939
Latimeria chalumnae	102357863		LATCH01126
Myotis lucifugus	102426743		MYOLU00159
Pelodiscus sinensis	102463378		PELSI08969
Vicugna pacos	102540512		VICPA01430
Peromyscus maniculatus bairdii	102913703	230844_0:003dc7

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GlyComb

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements