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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
endoplasmic reticulum aminopeptidase 1
Summary
- Gene Symbol
-
- Erap1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Adaptive immunity
- Aminopeptidase
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9EQH2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| positive regulation of angiogenesis | ||
| adaptive immune response | ||
| protein catabolic process | ||
| membrane protein ectodomain proteolysis |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum lumen | ||
| extracellular region | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| zinc ion binding | ||
| aminopeptidase activity | ||
| tumor necrosis factor receptor binding | ||
| metalloexopeptidase activity | ||
| endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- endoplasmic reticulum aminopeptidase 1
- Functional Category
-
- E: Amino acid transport and metabolism
- T: Signal transduction mechanisms
- U: Intracellular trafficking, secretion, and vesicular transport
| Gene Ontology |
|---|
| aminopeptidase activity |
| hydrolase activity |
| metal ion binding |
| metalloaminopeptidase activity |
| metallopeptidase activity |
| peptide binding |
| peptide catabolic process |
| proteolysis |
| zinc ion binding |
| InterPro |
|---|
| ERAP1-like C-terminal domain |
| Peptidase M1, membrane alanine aminopeptidase |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13129 | severe pre-eclampsia | |
| DOID:2871 | endometrial carcinoma | |
| DOID:2893 | cervix carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 118892447 | BALMU06241 | |||
| 119809084 | 1047088_0:001347 | |||
| 121455719 | 111838_0:0023e1 | |||
| 122117152 | 105255_0:00294b | |||
| 122223054 | PANLE13165 | |||
| 124082368 | 9995_0:0006ae | |||
| 124987254 | 30640_0:00236b | |||
| 125340069 | 214514_0:0044be | |||
| 125393941 | 447135_0:00076a | |||
| 126488589 | 100897_0:004018 |
