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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
endoplasmic reticulum aminopeptidase 1
Summary
- Gene Symbol
-
- Erap1
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Adaptive immunity
- Aminopeptidase
- Disulfide bond
- Endoplasmic reticulum
- Glycoprotein
- Metal-binding
- Metalloprotease
- Reference proteome
- Signal-anchor
- Transmembrane helix
- Zinc
- Proteins
| UniProt | Protein Name |
|---|---|
| Q9EQH2 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| positive regulation of angiogenesis | ||
| adaptive immune response | ||
| protein catabolic process | ||
| membrane protein ectodomain proteolysis |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| membrane | ||
| endoplasmic reticulum membrane | ||
| endoplasmic reticulum lumen | ||
| extracellular region | ||
| extracellular space |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| zinc ion binding | ||
| aminopeptidase activity | ||
| tumor necrosis factor receptor binding | ||
| metalloexopeptidase activity | ||
| endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Rodentia
- Group Name
- endoplasmic reticulum aminopeptidase 1
- Functional Category
-
- E: Amino acid transport and metabolism
- T: Signal transduction mechanisms
- U: Intracellular trafficking, secretion, and vesicular transport
| Gene Ontology |
|---|
| aminopeptidase activity |
| hydrolase activity |
| metal ion binding |
| metalloaminopeptidase activity |
| metallopeptidase activity |
| peptide binding |
| peptide catabolic process |
| proteolysis |
| zinc ion binding |
| InterPro |
|---|
| ERAP1-like C-terminal domain |
| Peptidase M1, membrane alanine aminopeptidase |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:13129 | severe pre-eclampsia | |
| DOID:2871 | endometrial carcinoma | |
| DOID:2893 | cervix carcinoma |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 103224968 | CHLSB14223 | |||
| 103257319 | CARSF09056 | |||
| 103672205 | URSMA24644 | |||
| 103732023 | 1026970_0:0010ed | NANGA16671 | ||
| 104654547 | RHIRO38467 | |||
| 104860603 | 885580_0:000446 | |||
| 105304324 | PTEVA13464 | |||
| 105484070 | MACNE40284 | |||
| 105546282 | MANLE11666 | |||
| 105599042 | CERAT06893 |
