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Guidelines

MIRAGE

tubulin beta 1 class VI

Summary

Gene Symbol

TUBB1

Organism

Homo sapiens (human)

External Links

NCBI Gene

81027

PubChem

81027

Alliance of Genome Resources

HGNC:16257

Annotation

Keyword

Cytoskeleton
Direct protein sequencing
Disease variant
GTP-binding
Isopeptide bond
Magnesium
Metal-binding
Microtubule
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H4B7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA
mitotic cell cycle	IBA
platelet formation	IEA
thyroid gland development	IEA
microtubule polymerization	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

spindle organization [inference]

spindle assembly

microtubule polymerization or depolymerization [inference]

microtubule polymerization

cell cycle [inference]

mitotic cell cycle

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

cell cycle process [inference]

spindle organization [inference]

spindle assembly

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

platelet formation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

spindle organization [inference]

spindle assembly

microtubule polymerization or depolymerization [inference]

microtubule polymerization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

spindle assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

microtubule polymerization

supramolecular fiber organization [inference]

microtubule polymerization

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

platelet formation

anatomical structure development [inference]

animal organ development [inference]

gland development [inference]

thyroid gland development

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

platelet formation

localization [inference]

establishment of localization [inference]

transport [inference]

hormone transport [inference]

thyroid hormone transport

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

thyroid hormone transport

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	18849486
cytoplasm	IBA
microtubule	IBA
microtubule cytoskeleton	IDA
intercellular bridge	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton [inference]

microtubule cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intercellular bridge

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GTPase activity	IEA
structural constituent of cytoskeleton	IBA
GTP binding	IBA
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
GTP binding
cytoskeleton organization
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 8** entries
InterPro
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090102	autosomal dominant isolated macrothrombocytopenia 1	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Cricetulus griseus	100772797		CRIGR02450
Sarcophilus harrisii	100930400		SARHA03230
Otolemur garnettii	100941657		OTOGA13875
Pan paniscus	100978646		PANPA22675
Papio anubis	101005758		PAPAN11264
Saimiri boliviensis boliviensis	101041752		SAIBB21390
Ovis aries	101115144		SHEEP04482
Gorilla gorilla gorilla	101135202		GORGO22233
Octodon degus	101583106		OCTDE25967
Jaculus jaculus	101614060		JACJA21486

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025