calreticulin

Summary
Gene Symbol
  • CALR
Aliases
  • CRT
  • FLJ26680
  • RO
  • SSA
  • Sicca syndrome antigen A (autoantigen Ro; calreticulin)
  • autoantigen Ro
  • cC1qR
  • calregulin
Organism
Homo sapiens (human)
External Links
NCBI Gene
811
HGNC
1455
KEGG Gene ID
hsa:811
PubChem
811
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Calcium
  • Chaperone
  • Cytoplasm
  • Cytoplasmic vesicle
  • Direct protein sequencing
  • Disulfide bond
  • Endoplasmic reticulum
  • Extracellular matrix
  • Glycoprotein
  • Hydroxylation
  • Lectin
  • Lysosome
  • Metal-binding
  • Reference proteome
  • Repeat
  • Sarcoplasmic reticulum
  • Signal
  • Zinc
Proteins
Displaying all 2 entries
UniProt Protein Name
P27797
  • CRP55
  • Calregulin
  • Endoplasmic reticulum resident protein 60
  • HACBP
  • grp60
V9HW88
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Displaying entries 16 - 19 of 19 in total
GO Term Evidence Code PMID
unfolded protein binding
molecular sequestering activity
RNA binding
peptide binding
Human Protein Atlas
ENSG00000179218

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K08057
Name
calreticulin
References
Disease
Disease Ontology
Displaying entries 21 - 30 of 410 in total
DO ID Disease Name Source
DOID:0050866 oral squamous cell carcinoma
DOID:0050902 medulloblastoma
DOID:0050908 myelodysplastic syndrome
DOID:0060058 lymphoma
DOID:0060180 colitis
DOID:0060189 ileitis
DOID:0060190 ileocolitis
DOID:0060224 atrial fibrillation
DOID:0060295 complement component 2 deficiency
DOID:0060297 complement component 4a deficiency
The Human Phenotype Ontology
Displaying entries 1 - 10 of 72 in total
HPO ID HPO Term
HP:0000006 Autosomal dominant inheritance
HP:0000505 Visual impairment
HP:0000952 Jaundice
HP:0000967 Petechiae
HP:0000978 Bruising susceptibility
HP:0000979 Purpura
HP:0000980 Pallor
HP:0001028 Hemangioma
HP:0001082 Cholecystitis
HP:0001394 Cirrhosis
Displaying all 5 entries
Disease ID Disease Name
ORPHA:824
  • primary myelofibrosis
OMIM:254450
  • primary myelofibrosis
ORPHA:3318
  • essential thrombocythemia
OMIM:187950
  • thrombocythemia 1
ORPHA:131
  • Budd-Chiari syndrome

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024