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pyruvate dehydrogenase kinase 2

Summary

Gene Symbol

Pdk2

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

81530

PubChem

81530

Alliance of Genome Resources

RGD:69428

Annotation

Keyword

3D-structure
ATP-binding
Kinase
Mitochondrion
Phosphoprotein
Proteomics identification
Pyruvate
Reference proteome
Transit peptide

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q64536	PDK P45 Pyruvate dehydrogenase kinase isoform 2
A0A8I6AJH2
Q9JID3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 33 in total

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GO Term	Evidence Code	PMID
regulation of gluconeogenesis	ISS
regulation of gluconeogenesis	ISO
regulation of gluconeogenesis	IEA
protein phosphorylation	IDA	12573248 15312755 9405293
protein phosphorylation	IMP	10698691

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-serine phosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein phosphorylation

peptidyl-serine phosphorylation

peptidyl-amino acid modification [inference]

peptidyl-serine modification [inference]

peptidyl-serine phosphorylation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phosphorylation [inference]

protein phosphorylation

peptidyl-serine phosphorylation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

regulation of pH

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

response to chemical [inference]

response to nutrient [inference]

cellular response to nutrient

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to nutrient

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to nutrient

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

biological regulation [inference]

regulation of pH

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of amide metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of small molecule metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process

regulation of gluconeogenesis

regulation of carbohydrate biosynthetic process [inference]

regulation of gluconeogenesis

regulation of lipid metabolic process [inference]

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

insulin receptor signaling pathway

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling

regulation of cellular metabolic process [inference]

regulation of cellular ketone metabolic process

regulation of fatty acid metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of nucleobase-containing compound metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of cellular biosynthetic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of sulfur metabolic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of nucleotide metabolic process [inference]

regulation of nucleotide biosynthetic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

regulation of purine nucleotide metabolic process [inference]

regulation of purine nucleotide biosynthetic process [inference]

regulation of acyl-CoA biosynthetic process [inference]

regulation of acetyl-CoA biosynthetic process from pyruvate

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
mitochondrion	ISO
mitochondrion	IBA
mitochondrial matrix	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

oxidoreductase complex [inference]

pyruvate dehydrogenase complex

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein serine/threonine kinase activity	IDA	11486000
pyruvate dehydrogenase (acetyl-transferring) kinase activity	ISO
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IDA	11486000 12573248 15312755 9405293
pyruvate dehydrogenase (acetyl-transferring) kinase activity	IMP	10698691

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pyruvate dehydrogenase kinase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
pyruvate dehydrogenase (acetyl-transferring) kinase activity
regulation of glucose metabolic process
transferase activity

Displaying **all 6** entries
InterPro
Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain superfamily
Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
Histidine kinase domain
Histidine kinase/HSP90-like ATPase superfamily
Histidine kinase/HSP90-like ATPase
PDK/BCKDK protein kinase

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
pyruvate dehydrogenase complex	PMID:12573248

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements