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GW repeat- and PHD finger-containing protein NERD

Summary

Gene Symbol

NERD

Organism

Arabidopsis thaliana (thale cress)

External Links

NCBI Gene: 816147
PubChem: 816147

Annotation

Keyword

Coiled coil
DNA-binding
Nucleus
Phosphoprotein
Proteomics identification
RNA-mediated gene silencing
Reference proteome
Repeat
Transcription regulation
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9SIV5	Protein Needed for RDR2-independent DNA methylation
A0A1P8B1D0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
gene silencing by RNA-directed DNA methylation

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

heterochromatin organization [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

regulatory ncRNA-mediated gene silencing [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

regulatory ncRNA-mediated heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

facultative heterochromatin formation [inference]

DNA methylation-dependent heterochromatin formation [inference]

gene silencing by RNA-directed DNA methylation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	ISM
nucleus	IDA	22940247
cytoplasm	ISM

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
protein binding	IPI	22940247
histone binding	IDA	22940247
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding

histone binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

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Last updated: April 6, 2026

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Acknowledgements