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diaphanous related formin 3

Summary

Gene Symbol

DIAPH3

Organism

Homo sapiens (human)

External Links

NCBI Gene

81624

PubChem

81624

Alliance of Genome Resources

HGNC:15480

Annotation

Keyword

3D-structure
Alternative splicing
Coiled coil
Cytoplasm
Neuropathy
Non-syndromic deafness
Nucleus
Phosphoprotein
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DPV3
Q9NSV4	Diaphanous-related formin-3 MDia2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	IEA
cytoskeleton organization	ISS
negative regulation of microtubule depolymerization	IEA
chromosome segregation	IEA
integrin-mediated signaling pathway	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule polymerization

establishment or maintenance of cell polarity [inference]

establishment of cell polarity

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

vesicle-mediated transport [inference]

endosomal transport

cell cycle process [inference]

chromosome segregation

actin filament-based process [inference]

actin cytoskeleton organization

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

neuron differentiation [inference]

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation

cellular localization [inference]

intracellular transport [inference]

endosomal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

microtubule cytoskeleton organization [inference]

microtubule polymerization or depolymerization [inference]

microtubule polymerization

actin cytoskeleton organization

vesicle organization [inference]

vesicle fusion [inference]

autophagosome-lysosome fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

autophagosome-lysosome fusion

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

cellular component disassembly [inference]

enucleation [inference]

erythrocyte enucleation

cellular component assembly [inference]

actin filament bundle assembly

protein-containing complex assembly [inference]

protein polymerization [inference]

podosome assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

podosome assembly

cell projection organization

protein-containing complex organization [inference]

protein-containing complex remodeling

protein-containing complex assembly [inference]

protein polymerization [inference]

podosome assembly

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

autophagosome-lysosome fusion

supramolecular fiber organization [inference]

actin filament organization [inference]

actin polymerization or depolymerization [inference]

actin filament polymerization

actin filament bundle organization [inference]

actin filament bundle assembly

microtubule polymerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

head development

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

myeloid cell differentiation [inference]

myeloid leukocyte differentiation [inference]

macrophage differentiation

neuron differentiation [inference]

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport

intracellular transport [inference]

endosomal transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

regulation of microtubule-based process [inference]

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of cytoskeleton organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of microtubule cytoskeleton organization [inference]

regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein-containing complex disassembly [inference]

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

regulation of protein depolymerization [inference]

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of cytoskeleton organization [inference]

negative regulation of microtubule polymerization or depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of protein-containing complex disassembly [inference]

negative regulation of protein depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

regulation of supramolecular fiber organization [inference]

regulation of microtubule depolymerization [inference]

negative regulation of microtubule depolymerization

negative regulation of supramolecular fiber organization [inference]

negative regulation of microtubule depolymerization

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
ESCRT I complex	IEA
spindle pole	IEA
nucleus	ISS
cytoplasm	ISS
microtubule organizing center	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

filamentous actin

ESCRT complex [inference]

ESCRT I complex

membrane protein complex [inference]

ESCRT I complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

cleavage furrow

cell junction [inference]

synapse [inference]

ribbon synapse

actin filament bundle

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

stereocilia tip-link density

Displaying **all 5** entries
GO Term	Evidence Code	PMID
actin binding	IEA
microtubule binding	IEA
small GTPase binding	IEA
protein homodimerization activity	IEA
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

tubulin binding [inference]

microtubule binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cadherin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Formin

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
actin binding
actin cytoskeleton organization

Displaying **all 7** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Formin, FH2 domain superfamily
Formin, FH2 domain
Formin, FH3 domain
Formin, GTPase-binding domain
Rho GTPase-binding/formin homology 3 (GBD/FH3) domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060690	autosomal dominant auditory neuropathy 1	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 47 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	1729	SGD:S000005215
Saccharomyces cerevisiae S288C	23002	SGD:S000005215
Mus musculus	56419		MOUSE13688
Xenopus tropicalis	81624	Xenbase:XB-GENE-868499
Rattus norvegicus	290396		RATNO09726
Pan troglodytes	452752		PANTR07856
Canis lupus familiaris	485474		CANLF08740
Bos taurus	525628		BOVIN03581
Macaca mulatta	695990		MACMU16683
Xenopus tropicalis	855450	Xenbase:XB-GENE-868499