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LIF receptor subunit alpha

Summary

Gene Symbol

Lifr

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

81680

PubChem

81680

Alliance of Genome Resources

RGD:621431

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G3V7K2
O70535
A6KGG5

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
positive regulation of cell population proliferation	ISO
positive regulation of cell population proliferation	IBA
positive regulation of cell population proliferation	IEA
negative regulation of muscle cell apoptotic process	IMP	15927854
response to organic cyclic compound

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

cytokine-mediated signaling pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure development [inference]

regeneration [inference]

animal organ regeneration

animal organ development [inference]

animal organ regeneration

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

leukemia inhibitory factor signaling pathway

cytokine-mediated signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of muscle cell apoptotic process

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
external side of plasma membrane	IBA
receptor complex	ISO
receptor complex	IBA
receptor complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
cytokine receptor activity	IBA
cytokine receptor activity	IEA
ciliary neurotrophic factor receptor activity	ISO
leukemia inhibitory factor receptor activity	ISO
leukemia inhibitory factor receptor activity	IMP	14638908

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

ciliary neurotrophic factor receptor binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

immune receptor activity [inference]

cytokine receptor activity

ciliary neurotrophic factor receptor activity

leukemia inhibitory factor receptor activity

oncostatin-M receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

LIF receptor

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
I: Lipid transport and metabolism

Displaying **all 3** entries
InterPro
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3977	Xenbase:XB-GENE-485214	HUMAN78945
Danio rerio	9180	ZFIN:ZDB-GENE-050327-16
Mus musculus	16880	Xenbase:XB-GENE-485214	MOUSE15251
Danio rerio	18414	ZFIN:ZDB-GENE-050327-16
Xenopus tropicalis	81680	Xenbase:XB-GENE-485214
Danio rerio	310132	ZFIN:ZDB-GENE-080107-2
Canis lupus familiaris	449478		CANLF14998
Bos taurus	539504		BOVIN16029
Macaca mulatta	694139		MACMU39667
Pan troglodytes	738797		PANTR35679