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Guidelines

MIRAGE

symplekin scaffold protein

Summary

Gene Symbol

SYMPK

Organism

Homo sapiens (human)

External Links

NCBI Gene

8189

PubChem

8189

Alliance of Genome Resources

HGNC:22935

Annotation

Keyword

3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Cytoskeleton
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Repeat
Tight junction
Ubl conjugation
mRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92797

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mRNA processing	IEA
cell adhesion	IEA
negative regulation of protein binding	IMP	29158257

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular process [inference]

cell adhesion

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA metabolic process [inference]

mRNA processing

biological regulation [inference]

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of binding [inference]

negative regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

negative regulation of protein binding

negative regulation of binding [inference]

negative regulation of protein binding

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleoplasm	TAS
nucleoplasm	IDA	8769423
cytoplasm	IDA	8769423
cytosol	IDA
mRNA cleavage and polyadenylation specificity factor complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

mRNA cleavage factor complex [inference]

mRNA cleavage and polyadenylation specificity factor complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

nuclear body

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

tight junction [inference]

bicellular tight junction

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

ribonucleoprotein granule [inference]

nuclear stress granule

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

ribonucleoprotein granule [inference]

nuclear stress granule

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear stress granule

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	14707147 18288197 18688255 20861839 26496610 32814053 33961781 34819669 35177536

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

symplekin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis

Displaying **all 2** entries
Gene Ontology
mRNA polyadenylation
mRNA processing

Displaying **all 5** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Symplekin C-terminal
Symplekin/Pta1, N-terminal
Symplekin/Pta1

Ortholog

Displaying entries **1 - 10** of 75 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8189	Xenbase:XB-GENE-941660
Mus musculus	68188		MOUSE53007
Rattus norvegicus	292683		RATNO18938
Pan troglodytes	456142		PANTR18692
Canis lupus familiaris	476431		CANLF00914
Danio rerio	570858		DANRE36414
Macaca mulatta	722436		MACMU20296
Monodelphis domestica	100010885		MONDO24295
Equus caballus	100070949		HORSE02475
Pongo abelii	100174376		PONAB15246

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025