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calpain 1

Summary

Gene Symbol

CAPN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

823

PubChem

823

Alliance of Genome Resources

HGNC:1476

JoGo

CAPN1

TogoVar

CAPN1

Annotation

Keyword

3D-structure
Acetylation
Autocatalytic cleavage
Calcium
Cell membrane
Cytoplasm
Disease variant
Hereditary spastic paraplegia
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Thiol protease

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DWH5	Calcium-activated neutral proteinase 1 Calpain mu-type Calpain-1 large subunit Micromolar-calpain
B2RDI5	Calcium-activated neutral proteinase 1 Calpain mu-type Calpain-1 large subunit Micromolar-calpain
P07384	Calcium-activated neutral proteinase 1 Calpain mu-type Calpain-1 large subunit Cell proliferation-inducing gene 30 protein Micromolar-calpain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
proteolysis	ISS
proteolysis	NAS	16411745
proteolysis	IDA	16411745 21531719 2400579 2407243
proteolysis	IBA
positive regulation of cell population proliferation	TAS	8702541

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

catabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

protein metabolic process [inference]

proteolysis

self proteolysis

receptor metabolic process [inference]

receptor catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

cellular metabolic process [inference]

cellular catabolic process [inference]

receptor catabolic process

multicellular organismal process [inference]

tissue remodeling [inference]

mammary gland involution

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

glutamate receptor signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

ligand-gated ion channel signaling pathway [inference]

ionotropic glutamate receptor signaling pathway [inference]

NMDA selective glutamate receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of autophagy [inference]

regulation of macroautophagy

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of molecular function [inference]

regulation of catalytic activity

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cornified envelope	IEA
extracellular region	TAS
cytoplasm	IBA
mitochondrion	IEA
lysosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

caspase complex [inference]

calpain complex

cellular anatomical entity [inference]

membrane

plasma membrane

cornified envelope

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

ficolin-1-rich granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
calcium-dependent cysteine-type endopeptidase activity	ISS
calcium-dependent cysteine-type endopeptidase activity	TAS	17526495
calcium-dependent cysteine-type endopeptidase activity	IDA	16411745 19617626 2407243
calcium-dependent cysteine-type endopeptidase activity	IBA
calcium ion binding	IDA	9271093