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calpain 3

Summary

Gene Symbol

CAPN3

Organism

Homo sapiens (human)

External Links

NCBI Gene

825

PubChem

825

Alliance of Genome Resources

HGNC:1480

JoGo

CAPN3

TogoVar

CAPN3

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Cytoplasm
Disease variant
Limb-girdle muscular dystrophy
Membrane
Metal-binding
Nucleus
Proteomics identification
Reference proteome
Repeat
Thiol protease

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P20807	Calcium-activated neutral proteinase 3 Calpain L3 Calpain p94 Muscle-specific calcium-activated neutral protease 3 New calpain 1
A0A0S2Z3E1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 35 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	18310072 19386580 20694146 9642272
proteolysis	IBA
apoptotic process	TAS	19386580
muscle organ development	TAS	9642272
positive regulation of satellite cell activation involved in skeletal muscle regeneration	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

calcium-dependent self proteolysis

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

calcium-dependent self proteolysis

protein catabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

self proteolysis

calcium-dependent self proteolysis

protein catabolic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

self proteolysis

calcium-dependent self proteolysis

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cell cycle process [inference]

G1 to G0 transition [inference]

G1 to G0 transition involved in cell differentiation

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

protein-containing complex assembly

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

myofibril assembly

protein-containing complex organization [inference]

protein-containing complex assembly

supramolecular fiber organization [inference]

myofibril assembly

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myofibril assembly

anatomical structure development [inference]

animal organ development [inference]

muscle organ development

muscle structure development

muscle organ development

homeostatic process [inference]

cellular homeostasis [inference]

muscle cell cellular homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

response to salt stress [inference]

cellular response to salt stress

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

response to abiotic stimulus [inference]

response to osmotic stress [inference]

response to salt stress [inference]

cellular response to salt stress

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

response to activity [inference]

response to muscle activity

response to chemical [inference]

response to organic substance [inference]

response to calcium ion

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to osmotic stress [inference]

cellular response to salt stress

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein sumoylation [inference]

negative regulation of protein sumoylation

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein sumoylation [inference]

negative regulation of protein sumoylation

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein sumoylation [inference]

negative regulation of protein sumoylation

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of developmental growth [inference]

regulation of skeletal muscle tissue regeneration [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cell activation [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of monoatomic ion transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein sumoylation

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

regulation of response to external stimulus [inference]

regulation of skeletal muscle tissue regeneration [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of myoblast differentiation

regulation of developmental growth [inference]

regulation of skeletal muscle tissue regeneration [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of developmental process [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of multicellular organismal development [inference]

regulation of skeletal muscle tissue regeneration [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell differentiation [inference]

regulation of myoblast differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of calcium ion transmembrane transport [inference]

positive regulation of release of sequestered calcium ion into cytosol

positive regulation of cell activation [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cell activation [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of cell activation [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of sequestering of calcium ion [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

positive regulation of release of sequestered calcium ion into cytosol

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of cell activation [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of multicellular organismal development [inference]

regulation of skeletal muscle tissue regeneration [inference]

regulation of satellite cell activation involved in skeletal muscle regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

positive regulation of skeletal muscle tissue regeneration [inference]

positive regulation of satellite cell activation involved in skeletal muscle regeneration

regulation of biological quality [inference]

regulation of protein stability [inference]

protein destabilization

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

regulation of catalytic activity

regulation of DNA-binding transcription factor activity [inference]

positive regulation of DNA-binding transcription factor activity [inference]

positive regulation of NF-kappaB transcription factor activity

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	19386580
nucleolus	IDA	27657329
cytoplasm	IDA	19386580 19556129
cytoplasm	IBA
cytosol	ISS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

contractile fiber [inference]

myofibril

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

contractile fiber [inference]

myofibril

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

contractile fiber [inference]

myofibril

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
catalytic activity	IDA	9642272
calcium-dependent cysteine-type endopeptidase activity	ISS
calcium-dependent cysteine-type endopeptidase activity	TAS	9642272
calcium-dependent cysteine-type endopeptidase activity	IBA
calcium ion binding	ISS

GO Hierarchy

molecular function

catalytic activity

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity [inference]

calcium-dependent cysteine-type endopeptidase activity

structural molecule activity [inference]

structural constituent of muscle

binding [inference]

protein binding

cytoskeletal protein binding [inference]

titin binding

identical protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

alkali metal ion binding [inference]

sodium ion binding

molecular adaptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

ligase regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

calpain

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
calcium-dependent cysteine-type endopeptidase activity
hydrolase activity
proteolysis

Displaying **all 8** entries
InterPro
Calpain large subunit, domain III superfamily
Calpain subdomain III
Cysteine peptidase, cysteine active site
Papain-like cysteine peptidase superfamily
Peptidase C2, calpain family
Peptidase C2, calpain, catalytic domain
Peptidase C2, calpain, domain III
Peptidase C2, calpain, large subunit, domain III

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110273	autosomal dominant limb-girdle muscular dystrophy	Alliance of Genome Resources
DOID:0110275	autosomal recessive limb-girdle muscular dystrophy type 2A	Alliance of Genome Resources
DOID:9884	muscular dystrophy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements