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RAB33B, member RAS oncogene family

Summary

Gene Symbol

RAB33B

Organism

Homo sapiens (human)

External Links

NCBI Gene

83452

PubChem

83452

Alliance of Genome Resources

HGNC:16075

JoGo

RAB33B

TogoVar

RAB33B

Annotation

Keyword

3D-structure
Autophagy
Disease variant
Dwarfism
GTP-binding
Golgi apparatus
Hydrolase
Membrane
Methylation
Prenylation
Protein transport
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A494C0Z5
Q9H082

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
autophagosome assembly	IBA
regulation of cell growth	IMP	20163571
intra-Golgi vesicle-mediated transport	IMP	20163571
protein transport	IEA
regulation of exocytosis	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rab protein signal transduction

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

intra-Golgi vesicle-mediated transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

establishment of protein localization [inference]

protein transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skeletal system morphogenesis

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

Golgi vesicle transport [inference]

intra-Golgi vesicle-mediated transport

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to Golgi apparatus

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of secretion by cell [inference]

regulation of exocytosis

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of constitutive secretory pathway [inference]

negative regulation of constitutive secretory pathway

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of constitutive secretory pathway [inference]

negative regulation of constitutive secretory pathway

regulation of retrograde vesicle-mediated transport, Golgi to ER

regulation of growth [inference]

regulation of cell growth

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rab protein signal transduction

regulation of cell population proliferation [inference]

regulation of epithelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of cellular component organization [inference]

regulation of cell growth

regulation of organelle organization [inference]

regulation of Golgi organization

regulation of vesicle-mediated transport [inference]

regulation of exocytosis

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of constitutive secretory pathway [inference]

negative regulation of constitutive secretory pathway

regulation of retrograde vesicle-mediated transport, Golgi to ER

regulation of secretion by cell [inference]

regulation of exocytosis

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

regulation of constitutive secretory pathway [inference]

negative regulation of constitutive secretory pathway

negative regulation of secretion by cell [inference]

negative regulation of exocytosis [inference]

negative regulation of constitutive secretory pathway

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
endosome	IBA
Golgi apparatus	IDA	23042644
Golgi apparatus	IBA
Golgi lumen	IDA	18448665

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

presynapse

Displaying **all 4** entries
GO Term	Evidence Code	PMID
GTPase activity	IMP	21808068
GTPase activity	IBA
protein binding	IPI	21808068 23091056 32296183 33961781
GTP binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ras-related protein Rab-33B-like

Functional Category

Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
GTP binding
Rab protein signal transduction
nucleotide binding

Displaying **all 4** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Rab33A/B
Small GTP-binding protein domain
Small GTPase

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081271	Smith-McCort dysplasia 2	Alliance of Genome Resources

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Last updated: April 6, 2026

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Acknowledgements