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neurofilament light chain

Summary

Gene Symbol

Nefl

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

83613

PubChem

83613

Alliance of Genome Resources

RGD:621458

Annotation

Keyword

Acetylation
Cell projection
Coiled coil
Cytoplasm
Cytoskeleton
Direct protein sequencing
Glycoprotein
Intermediate filament
Methylation
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P19527	68 kDa neurofilament protein Neurofilament triplet L protein
A6K6Q9	Neurofilament triplet L protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
response to toxic substance	IEP	18001836
axonogenesis	ISO
intermediate filament bundle assembly	ISO
anterograde axonal transport	ISO
intermediate filament organization	ISO

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

intermediate filament bundle assembly

neurofilament bundle assembly

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

intermediate filament bundle assembly

neurofilament bundle assembly

postsynaptic cytoskeleton organization [inference]

postsynaptic intermediate filament cytoskeleton organization

cellular component assembly [inference]

intermediate filament bundle assembly

neurofilament bundle assembly

protein-containing complex assembly [inference]

protein polymerization

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

axon development [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

protein-containing complex organization [inference]

intermediate filament polymerization or depolymerization

protein-containing complex assembly [inference]

protein polymerization

supramolecular fiber organization [inference]

intermediate filament organization

intermediate filament bundle assembly

neurofilament bundle assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

axonogenesis

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

locomotion

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to chemical [inference]

response to toxic substance

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to acrylamide

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to corticosterone

response to mineralocorticoid [inference]

response to corticosterone

response to alcohol [inference]

response to corticosterone

response to ketone [inference]

response to corticosterone

response to inorganic substance [inference]

response to sodium arsenite

response to arsenic-containing substance [inference]

response to sodium arsenite

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to acrylamide

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to corticosterone

response to peptide [inference]

response to peptide hormone

response to ketone [inference]

response to corticosterone

response to acrylamide

response to salt [inference]

response to sodium arsenite

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle localization [inference]

mitochondrion localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of synapse maturation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

regulation of synapse organization [inference]

regulation of synapse maturation

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

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GO Term	Evidence Code	PMID
intermediate filament	IBA ISO
presynaptic intermediate filament cytoskeleton	ISO
neurofilament	IDA ISO	7721944
axon	IBA IDA ISO	8737171
cholinergic synapse	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

cytosol

cell junction [inference]

synapse [inference]

site of polarized growth [inference]

growth cone

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

axon

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton [inference]

presynaptic cytoskeleton [inference]

presynaptic intermediate filament cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton [inference]

presynaptic cytoskeleton [inference]

presynaptic intermediate filament cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

postsynapse

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

neurofilament

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GO Term	Evidence Code	PMID
protein-macromolecule adaptor activity	ISO
protein domain specific binding	IPI	16819285
structural constituent of postsynaptic intermediate filament cytoskeleton	IBA ISO
identical protein binding	ISO
protein-containing complex binding	IDA	9388258

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

structural constituent of postsynaptic intermediate filament cytoskeleton

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic intermediate filament cytoskeleton

binding [inference]

protein binding [inference]

enzyme binding [inference]

phospholipase binding

protein-containing complex binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 3** entries
Location	References
axon	PMID:8737171
neurofilament	PMID:7721944
growth cone	PMID:12226091

Disease

Disease Ontology

Displaying entries **1 - 10** of 29 in total

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DO ID	Disease Name	Source
DOID:0050328	congenital hypothyroidism	Alliance of Genome Resources
DOID:0050433	fatal familial insomnia	Alliance of Genome Resources
DOID:0080294	Charcot-Marie-Tooth disease dominant intermediate G	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0080832	mild cognitive impairment	Alliance of Genome Resources
DOID:0110149	Charcot-Marie-Tooth disease type 1F	Alliance of Genome Resources
DOID:0110165	Charcot-Marie-Tooth disease type 2E	Alliance of Genome Resources
DOID:10595	Charcot-Marie-Tooth disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements