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itchy E3 ubiquitin protein ligase

Summary

Gene Symbol

ITCH

Organism

Homo sapiens (human)

External Links

NCBI Gene

83737

PubChem

83737

Alliance of Genome Resources

HGNC:13890

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Antiviral defense
Apoptosis
Cell membrane
Cytoplasm
Direct protein sequencing
Endosome
Host-virus interaction
Innate immunity
Nucleus
Phosphoprotein
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96J02	Atrophin-1-interacting protein 4 HECT-type E3 ubiquitin transferase Itchy homolog NFE2-associated polypeptide 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
regulation of cell growth	NAS	9462742
positive regulation of T cell anergy	IEA
T cell anergy	IEA
ubiquitin-dependent protein catabolic process	NAS	9462742
ubiquitin-dependent protein catabolic process	IDA	15678106

GO Hierarchy

biological process

immune system process [inference]

tolerance induction [inference]

lymphocyte anergy [inference]

T cell anergy

T cell tolerance induction [inference]

T cell anergy

immune response [inference]

innate immune response

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell proliferation

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

protein polyubiquitination [inference]

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process

proteasome-mediated ubiquitin-dependent protein catabolic process

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell proliferation

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

signal transduction [inference]

intracellular receptor signaling pathway [inference]

nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell activation [inference]

CD4-positive, alpha-beta T cell proliferation

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation [inference]

alpha-beta T cell proliferation [inference]

CD4-positive, alpha-beta T cell proliferation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

defense response to virus

defense response to other organism [inference]

innate immune response

defense response to symbiont [inference]

defense response to virus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of tolerance induction [inference]

positive regulation of tolerance induction [inference]

positive regulation of T cell tolerance induction [inference]

positive regulation of T cell anergy

positive regulation of lymphocyte anergy [inference]

positive regulation of T cell anergy

regulation of T cell tolerance induction [inference]

positive regulation of T cell tolerance induction [inference]

positive regulation of T cell anergy

regulation of T cell anergy [inference]

positive regulation of T cell anergy

regulation of lymphocyte anergy [inference]

regulation of T cell anergy [inference]

positive regulation of T cell anergy

positive regulation of lymphocyte anergy [inference]

positive regulation of T cell anergy

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

positive regulation of immune system process [inference]

positive regulation of tolerance induction [inference]

positive regulation of T cell tolerance induction [inference]

positive regulation of T cell anergy

positive regulation of lymphocyte anergy [inference]

positive regulation of T cell anergy

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of receptor catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

positive regulation of protein catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

regulation of receptor catabolic process [inference]

positive regulation of receptor catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

regulation of receptor catabolic process [inference]

positive regulation of receptor catabolic process

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein deubiquitination

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein deubiquitination

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

regulation of receptor catabolic process [inference]

positive regulation of receptor catabolic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein deubiquitination

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of growth [inference]

regulation of cell growth

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of tolerance induction [inference]

positive regulation of T cell tolerance induction [inference]

positive regulation of T cell anergy

positive regulation of lymphocyte anergy [inference]

positive regulation of T cell anergy

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of receptor catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

positive regulation of multicellular organismal process [inference]

positive regulation of tolerance induction [inference]

positive regulation of T cell tolerance induction [inference]

positive regulation of T cell anergy

positive regulation of lymphocyte anergy [inference]

positive regulation of T cell anergy

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to virus

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of defense response [inference]

negative regulation of defense response to virus

negative regulation of response to external stimulus [inference]

negative regulation of defense response to virus

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to virus

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of defense response to virus [inference]

negative regulation of defense response to virus

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of defense response to virus

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of defense response to virus [inference]

negative regulation of defense response to virus

negative regulation of response to stimulus [inference]

negative regulation of response to biotic stimulus [inference]

negative regulation of defense response to virus

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of defense response [inference]

negative regulation of defense response to virus

negative regulation of response to external stimulus [inference]

negative regulation of defense response to virus

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

negative regulation of defense response [inference]

negative regulation of defense response to virus

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of defense response to virus [inference]

negative regulation of defense response to virus

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

intracellular receptor signaling pathway [inference]

nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

regulation of receptor catabolic process [inference]

positive regulation of receptor catabolic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process

regulation of cell differentiation [inference]

regulation of hematopoietic progenitor cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

regulation of stem cell differentiation [inference]

regulation of hematopoietic stem cell differentiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of receptor catabolic process

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytoplasmic pattern recognition receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of cellular component organization [inference]

regulation of cell growth

regulation of cellular response to stress [inference]

regulation of stress-activated protein kinase signaling cascade [inference]

regulation of stress-activated MAPK cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of JNK cascade [inference]

negative regulation of JNK cascade

negative regulation of stress-activated protein kinase signaling cascade [inference]

negative regulation of stress-activated MAPK cascade [inference]

negative regulation of JNK cascade

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

regulation of type I interferon production [inference]

negative regulation of type I interferon production

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of CD4-positive, alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of tolerance induction [inference]

positive regulation of T cell tolerance induction [inference]

positive regulation of T cell anergy

positive regulation of lymphocyte anergy [inference]

positive regulation of T cell anergy

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of type I interferon production

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

negative regulation of CD4-positive, alpha-beta T cell activation [inference]

negative regulation of CD4-positive, alpha-beta T cell proliferation

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

regulation of DNA-binding transcription factor activity [inference]

negative regulation of DNA-binding transcription factor activity [inference]

negative regulation of NF-kappaB transcription factor activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytoplasm	IBA
mitochondrion	IC	27736772
early endosome	IDA	24790097
cytosol	TAS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

nucleoplasm

cytoplasm

cell cortex

cytosol

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

early endosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	EXP	34999730
protein binding	IPI	15051726 15678106 16888620 16908849 17028573 17174309 17592138 18334649 19580544 20068034 20392206 20491914 20676133 20818436 20858735 22009753 22057290 22810586 23146885 23236378 24790097 25436413 26854353 28514442 32814053 33961781 34927784 37100772 37219487 38270169 9647693
ligase activity	IEA
ubiquitin-like protein transferase activity	TAS
ubiquitin-ubiquitin ligase activity	IDA	29378950

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-ubiquitin ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

ubiquitin-ubiquitin ligase activity

ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity

ubiquitin-protein transferase activity

ubiquitin protein ligase activity

ubiquitin-ubiquitin ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

ubiquitin-ubiquitin ligase activity

binding [inference]

protein binding

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

chemokine receptor binding [inference]

CXCR chemokine receptor binding

cytokine receptor binding [inference]

chemokine receptor binding [inference]

CXCR chemokine receptor binding

enzyme binding [inference]

ubiquitin-like protein ligase binding

arrestin family protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

E3 ubiquitin-protein ligase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
proteasome-mediated ubiquitin-dependent protein catabolic process
protein ubiquitination
transferase activity

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
E3 ubiquitin-protein ligase, SMURF1 type
HECT domain
HECT, E3 ligase catalytic domain
WW domain superfamily
WW domain

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	11060	FB:FBgn0003557
Mus musculus	16396		MOUSE32207
Drosophila melanogaster	66894	FB:FBgn0003557
Xenopus tropicalis	83737	Xenbase:XB-GENE-976485
Rattus norvegicus	311567		RATNO26158
Pan troglodytes	458191		PANTR24683
Canis lupus familiaris	477199		CANLF09472
Bos taurus	508431		BOVIN05130
Macaca mulatta	707640		MACMU02195
Xenopus tropicalis	856862	Xenbase:XB-GENE-976485

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements