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acetylcholinesterase

Summary

Gene Symbol

Ache

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

83817

PubChem

83817

Alliance of Genome Resources

RGD:69313

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
GPI-anchor
Glycoprotein
Neurotransmitter degradation
Reference proteome
Secreted
Serine esterase
Signal
Synapse

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A9K3Y822
P37136
Q505J2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 32 in total

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GO Term	Evidence Code	PMID
regulation of receptor recycling	ISO
regulation of receptor recycling	IEA
osteoblast development	ISO
osteoblast development	IEA
acetylcholine catabolic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

ammonium ion metabolic process [inference]

choline metabolic process

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process

acetylcholine catabolic process

choline metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

catabolic process [inference]

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

organic substance metabolic process [inference]

acetate ester metabolic process [inference]

acetylcholine metabolic process

acetylcholine catabolic process

organonitrogen compound metabolic process [inference]

acetylcholine metabolic process

acetylcholine catabolic process

choline metabolic process

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

organic substance catabolic process [inference]

organonitrogen compound catabolic process [inference]

acetylcholine catabolic process

cellular process [inference]

cell adhesion

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

cellular developmental process [inference]

cell development [inference]

osteoblast development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

synapse assembly

cell junction organization [inference]

cell junction assembly [inference]

synapse assembly

synapse organization [inference]

synapse assembly

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

osteoblast development

animal organ development [inference]

brain development

retina development in camera-type eye

cellular developmental process [inference]

cell development [inference]

osteoblast development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to chemical [inference]

response to toxic substance [inference]

response to insecticide

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone [inference]

response to insulin

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to alcohol [inference]

response to ethanol

response to inorganic substance [inference]

response to metal ion [inference]

response to cadmium ion

response to nicotine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to ethanol

response to peptide [inference]

response to peptide hormone [inference]

response to insulin

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of receptor recycling

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of axonogenesis [inference]

positive regulation of axonogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

regulation of cellular process [inference]

signal transduction [inference]

postsynaptic signal transduction [inference]

acetylcholine receptor signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

positive regulation of axonogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

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GO Term	Evidence Code	PMID
extracellular region	ISO
extracellular region	IEA
basement membrane	ISO
basement membrane	IEA
extracellular space	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular region

synaptic cleft

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

synaptic membrane [inference]

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

neuromuscular junction

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

rough endoplasmic reticulum lumen

envelope [inference]

organelle envelope [inference]

nuclear envelope

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

cell body [inference]

neuronal cell body

side of membrane

external side of plasma membrane

presynapse [inference]

terminal bouton

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
acetylcholinesterase activity	ISO
acetylcholinesterase activity	IDA	126256 14646156 16052514 2731551 334962 3655326 4008917 6854006 8417155 8737018
acetylcholinesterase activity	IBA
acetylcholinesterase activity	IEA
cholinesterase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

cholinesterase activity

acetylcholinesterase activity

serine hydrolase activity

binding [inference]

protein binding [inference]

identical protein binding

protein homodimerization activity

laminin binding

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

protein-containing complex binding [inference]

collagen binding

extracellular matrix binding [inference]

laminin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Carboxylesterase

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
hydrolase activity

Displaying **all 4** entries
InterPro
Alpha/Beta hydrolase fold
Carboxylesterase type B, active site
Carboxylesterase type B, conserved site
Carboxylesterase, type B

Alliance of Genome Resources

Expression

Displaying **all 10** entries
Location	References
nuclear envelope	PMID:1133098
postsynaptic membrane	PMID:3655326
cell surface	PMID:2731551
membrane raft	PMID:20147288
endoplasmic reticulum lumen	PMID:1133098
neuronal cell body	PMID:1133098
dendrite	PMID:1133098
perinuclear region of cytoplasm	PMID:16052514
axon	PMID:1133098
presynaptic membrane	PMID:3655326

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OrthoDB (Group)

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Acknowledgements