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hemicentin 1

Summary

Gene Symbol

HMCN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

83872

PubChem

83872

Alliance of Genome Resources

HGNC:19194

Annotation

Keyword

Age-related macular degeneration
Alternative splicing
Basement membrane
Calcium
Cell division
Cell junction
Cytoplasm
Disease variant
Disulfide bond
EGF-like domain
Glycoprotein
Immunoglobulin domain
Reference proteome
Repeat
Signal
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
Q96RW7	Fibulin-6

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
homophilic cell adhesion via plasma membrane adhesion molecules	IBA
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
visual perception	IEA
response to bacterium	IEA
actin cytoskeleton organization	IMP	29488390

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

actin filament-based process [inference]

actin cytoskeleton organization

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

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GO Term	Evidence Code	PMID
basement membrane	ISS
cytoplasm	ISS
adherens junction	IBA
muscle tendon junction	ISS
cell cortex	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell cortex

membrane [inference]

plasma membrane region [inference]

cleavage furrow

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

cell-substrate junction [inference]

muscle tendon junction

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular matrix structural constituent	HDA	28344315
calcium ion binding	IEA
protein binding	IPI	19696174

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

hemicentin

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
InterPro
Immunoglobulin I-set
Immunoglobulin subtype 2
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110014	age related macular degeneration 1	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	83872	Xenbase:XB-GENE-6258572
Xenopus tropicalis	181187	Xenbase:XB-GENE-6258572
Caenorhabditis elegans	256158	WB:WBGene00001863
Rattus norvegicus	289094		RATNO07043
Pan troglodytes	457586		PANTR23224
Canis lupus familiaris	490318		CANLF17189
Bos taurus	521326		BOVIN08794
Mus musculus	545370	Xenbase:XB-GENE-6258572	MOUSE30774
Danio rerio	559150		DANRE18635
Macaca mulatta	714026		MACMU22456

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements