GlyCosmos Portal

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GO Term	Evidence Code	PMID
1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA IDA TAS	15157668 18305108 21477596 22942276
1-phosphatidylinositol-3-phosphate 5-kinase activity
kinase binding	IDA	15157668
1-phosphatidylinositol-5-kinase activity
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

phosphatidylinositol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000143398

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00889

Name

1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]

References

Rhea

RHEA:14425

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

Enzyme

2.7.1.68

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 12 in total

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DO ID	Disease Name	Source
DOID:0090053	episodic kinesigenic dyskinesia 1	DisGeNET
DOID:10283	prostate cancer	DisGeNET
DOID:10286	prostate carcinoma	DisGeNET
DOID:1520	colon carcinoma	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:162	cancer	DisGeNET Alliance of Genome Resources
DOID:1793	pancreatic cancer	DisGeNET
DOID:219	colon cancer	DisGeNET
DOID:235	colonic benign neoplasm	DisGeNET
DOID:4905	pancreatic carcinoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000420
Gene Name: phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	172184	WB:WBGene00004087
Drosophila melanogaster	37356	FB:FBgn0016984
Danio rerio	492549	ZFIN:ZDB-GENE-041111-123
Danio rerio	553629	ZFIN:ZDB-GENE-050522-517
Esox lucius	105008609		ESOLU27954
Salmo trutta	115177447		SALTR45094
Salmo trutta	115186869		SALTR45094
Gadus morhua	115554652		GADMO03366
Xiphophorus maculatus	102222920		XIPMA05265
Oreochromis niloticus	100701476		ORENI06153

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements