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adhesion G protein-coupled receptor V1

Summary

Gene Symbol

ADGRV1

Aliases

DKFZp761P0710
FEB4
KIAA0686
VLGR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

84059

HGNC

17416

PubChem

84059

Alliance of Genome Resources

HGNC:17416

Annotation

Keyword

Alternative splicing
Calcium
Cell membrane
Cell projection
Disulfide bond
G-protein coupled receptor
Hydrolase
Reference proteome
Repeat
Retinitis pigmentosa
Signal
Transmembrane helix
Usher syndrome
Vision

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8WXG9	G-protein coupled receptor 98 Monogenic audiogenic seizure susceptibility protein 1 homolog Usher syndrome type-2C protein Very large G-protein coupled receptor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	IEA
G protein-coupled receptor signaling pathway	ISS
negative regulation of adenylate cyclase activity	ISS
nervous system development	NAS	11606593
visual perception	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

self proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

self proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

self proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

self proteolysis

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

signal transduction [inference]

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

inner ear receptor cell stereocilium organization

multicellular organismal process [inference]

system process [inference]

nervous system process

sensory perception [inference]

sensory perception of light stimulus

visual perception

sensory perception of mechanical stimulus [inference]

sensory perception of sound

detection of mechanical stimulus involved in sensory perception of sound

photoreceptor cell maintenance

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

inner ear development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation [inference]

mechanoreceptor differentiation [inference]

inner ear receptor cell differentiation

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

response to chemical [inference]

response to organic substance [inference]

response to calcium ion [inference]

cellular response to calcium ion

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

response to oxygen-containing compound [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

response to salt [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of sound

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to calcium ion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

establishment of localization [inference]

establishment of protein localization

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

regulation of intracellular signal transduction [inference]

regulation of protein kinase A signaling [inference]

positive regulation of protein kinase A signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of protein kinase A signaling

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

maintenance of animal organ identity

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of biological quality [inference]

regulation of protein stability

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

regulation of catalytic activity [inference]

regulation of cyclase activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

regulation of adenylate cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of catalytic activity [inference]

negative regulation of cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

regulation of lyase activity [inference]

regulation of adenylate cyclase activity [inference]

negative regulation of adenylate cyclase activity

negative regulation of lyase activity [inference]

negative regulation of adenylate cyclase activity

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GO Term	Evidence Code	PMID
photoreceptor inner segment	IEA
stereocilia ankle link	ISS
stereocilia ankle link complex	ISS
cytoplasm	IDA	16434480
cytoplasm	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

photoreceptor inner segment

stereocilia coupling link [inference]

stereocilia ankle link

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

stereocilium membrane

periciliary membrane compartment

leading edge membrane [inference]

neuron projection membrane [inference]

stereocilium membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection [inference]

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
G-protein alpha-subunit binding	ISS
G-protein alpha-subunit binding	IBA
G protein-coupled receptor activity	ISS
G protein-coupled receptor activity	NAS	11606593
G protein-coupled receptor activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

binding [inference]

protein binding

G-protein alpha-subunit binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

G protein-coupled receptor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

cyclase inhibitor activity [inference]

adenylate cyclase inhibitor activity

cyclase regulator activity [inference]

cyclase inhibitor activity [inference]

adenylate cyclase inhibitor activity

adenylate cyclase regulator activity [inference]

adenylate cyclase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

cyclase inhibitor activity [inference]

adenylate cyclase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

adhesion G-protein coupled receptor V1

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
G-protein alpha-subunit binding
adenylate cyclase inhibitor activity
cell communication
cell surface receptor signaling pathway
cellular response to calcium ion
sensory perception of sound
visual perception

Displaying **all 6** entries
InterPro
Adhesion G-protein coupled receptor V1
CalX-like domain superfamily
Concanavalin A-like lectin/glucanase domain superfamily
EAR
GAIN domain superfamily
Na-Ca exchanger/integrin-beta4

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110839	Usher syndrome type 2C	Alliance of Genome Resources
DOID:0111305	familial febrile seizures 4	Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000359	Abnormality of the inner ear
HP:0000407	Sensorineural hearing impairment
HP:0000510	Rod-cone dystrophy
HP:0000512	Abnormal electroretinogram
HP:0000518	Cataract
HP:0000545	Myopia
HP:0000572	Visual loss
HP:0000575	Scotoma

Displaying **all 4** entries
Disease ID	Disease Name
ORPHA:36387	generalized epilepsy with febrile seizures plus
OMIM:605472	Usher syndrome type 2C
ORPHA:231178	Usher syndrome type 2
OMIM:604352	febrile seizures, familial, 4

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	84059	Xenbase:XB-GENE-1010012
Mus musculus	110789		MOUSE11278
Danio rerio	415105		DANRE36348
Pan troglodytes	461757		PANTR35130
Canis lupus familiaris	479153		CANLF11886
Bos taurus	537034		BOVIN33965
Macaca mulatta	697794		MACMU38588
Monodelphis domestica	100012465		MONDO16487
Equus caballus	100073239		HORSE08517
Taeniopygia guttata	100223389		TAEGU31328

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External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements